Clarithromycin and Fentanyl: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Fentanyl unless specifically directed by your doctor.
How Clarithromycin interacts with Fentanyl
Clarithromycin inhibits CYP3A4-mediated fentanyl metabolism, increasing fentanyl exposure and the risk of profound sedation and respiratory depression.
What you should do
Avoid concurrent use when possible. If unavoidable, reduce fentanyl exposure and institute close monitoring for sedation and respiratory depression, including after clarithromycin is stopped.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin inhibits CYP3A4-mediated fentanyl metabolism, increasing fentanyl exposure and the risk of profound sedat...
Action
Avoid concurrent use when possible. If unavoidable, reduce fentanyl exposure and institute close monitoring for sedation...
Frequently asked questions
Can I take Clarithromycin and Fentanyl together?
No — this combination should generally be avoided. Avoid concurrent use when possible. If unavoidable, reduce fentanyl exposure and institute close monitoring for sedation and respiratory depression, including after clarithromycin is stopped.
What is the severity of this interaction?
The interaction between Clarithromycin and Fentanyl is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4-mediated fentanyl metabolism, increasing fentanyl exposure and the risk of profound sedation and respiratory depression.
What should I do if I'm prescribed both?
Avoid concurrent use when possible. If unavoidable, reduce fentanyl exposure and institute close monitoring for sedation and respiratory depression, including after clarithromycin is stopped. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.