Clarithromycin and Eplerenone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Eplerenone unless specifically directed by your doctor.
How Clarithromycin interacts with Eplerenone
Clarithromycin strongly inhibits CYP3A4, the principal metabolic pathway for eplerenone, causing increased eplerenone concentrations and hyperkalaemia risk.
What you should do
Avoid co-administration. Select an alternative antibiotic or an alternative mineralocorticoid receptor antagonist strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4, the principal metabolic pathway for eplerenone, causing increased eplerenone co...
Action
Avoid co-administration. Select an alternative antibiotic or an alternative mineralocorticoid receptor antagonist strate...
Frequently asked questions
Can I take Clarithromycin and Eplerenone together?
No — this combination should generally be avoided. Avoid co-administration. Select an alternative antibiotic or an alternative mineralocorticoid receptor antagonist strategy.
What is the severity of this interaction?
The interaction between Clarithromycin and Eplerenone is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, the principal metabolic pathway for eplerenone, causing increased eplerenone concentrations and hyperkalaemia risk.
What should I do if I'm prescribed both?
Avoid co-administration. Select an alternative antibiotic or an alternative mineralocorticoid receptor antagonist strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.