Clarithromycin and Domperidone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Domperidone unless specifically directed by your doctor.
How Clarithromycin interacts with Domperidone
Clarithromycin inhibits CYP3A4 and prolongs QT interval, while domperidone is a CYP3A4 substrate with QT-prolonging potential. Combined exposure increases risk of torsades de pointes.
What you should do
Avoid this combination. Use an alternative antibiotic or antiemetic that does not meaningfully prolong QT interval.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin inhibits CYP3A4 and prolongs QT interval, while domperidone is a CYP3A4 substrate with QT-prolonging pote...
Action
Avoid this combination. Use an alternative antibiotic or antiemetic that does not meaningfully prolong QT interval.
Frequently asked questions
Can I take Clarithromycin and Domperidone together?
No — this combination should generally be avoided. Avoid this combination. Use an alternative antibiotic or antiemetic that does not meaningfully prolong QT interval.
What is the severity of this interaction?
The interaction between Clarithromycin and Domperidone is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 and prolongs QT interval, while domperidone is a CYP3A4 substrate with QT-prolonging potential. Combined exposure increases risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid this combination. Use an alternative antibiotic or antiemetic that does not meaningfully prolong QT interval. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.