Erythromycin and Pimozide: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erythromycin and Pimozide unless specifically directed by your doctor.
How Erythromycin interacts with Pimozide
Erythromycin inhibits CYP3A4-mediated pimozide clearance, and both drugs prolong cardiac repolarization, markedly increasing torsades de pointes risk.
What you should do
Concurrent use is contraindicated. Select an alternative antibiotic without clinically important CYP3A4 inhibition or QT effects.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin inhibits CYP3A4-mediated pimozide clearance, and both drugs prolong cardiac repolarization, markedly increa...
Action
Concurrent use is contraindicated. Select an alternative antibiotic without clinically important CYP3A4 inhibition or QT...
Frequently asked questions
Can I take Erythromycin and Pimozide together?
No — this combination should generally be avoided. Concurrent use is contraindicated. Select an alternative antibiotic without clinically important CYP3A4 inhibition or QT effects.
What is the severity of this interaction?
The interaction between Erythromycin and Pimozide is classified as Major — avoid combination. Erythromycin inhibits CYP3A4-mediated pimozide clearance, and both drugs prolong cardiac repolarization, markedly increasing torsades de pointes risk.
What should I do if I'm prescribed both?
Concurrent use is contraindicated. Select an alternative antibiotic without clinically important CYP3A4 inhibition or QT effects. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.