Citalopram and Methadone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Methadone unless specifically directed by your doctor.
How Citalopram interacts with Methadone
Both medicines inhibit cardiac repolarizing potassium currents and can additively prolong the QT interval, increasing torsades de pointes risk.
What you should do
Avoid the combination in patients with additional QT-risk factors and use a safer alternative when possible. If essential, obtain baseline and follow-up ECGs and correct electrolyte abnormalities.
Key facts
Severity
Major — avoid combination
Mechanism
Both medicines inhibit cardiac repolarizing potassium currents and can additively prolong the QT interval, increasing to...
Action
Avoid the combination in patients with additional QT-risk factors and use a safer alternative when possible. If essentia...
Frequently asked questions
Can I take Citalopram and Methadone together?
No — this combination should generally be avoided. Avoid the combination in patients with additional QT-risk factors and use a safer alternative when possible. If essential, obtain baseline and follow-up ECGs and correct electrolyte abnormalities.
What is the severity of this interaction?
The interaction between Citalopram and Methadone is classified as Major — avoid combination. Both medicines inhibit cardiac repolarizing potassium currents and can additively prolong the QT interval, increasing torsades de pointes risk.
What should I do if I'm prescribed both?
Avoid the combination in patients with additional QT-risk factors and use a safer alternative when possible. If essential, obtain baseline and follow-up ECGs and correct electrolyte abnormalities. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.