Citalopram and Hydroxychloroquine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Hydroxychloroquine unless specifically directed by your doctor.
How Citalopram interacts with Hydroxychloroquine
Both drugs inhibit cardiac potassium currents involved in repolarization and can prolong the QT interval. Their combined use increases the risk of torsades de pointes and sudden cardiac death.
What you should do
Avoid the combination when possible. If no alternative exists, correct electrolyte abnormalities, review other QT-prolonging drugs, and obtain baseline and follow-up ECGs.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit cardiac potassium currents involved in repolarization and can prolong the QT interval. Their combined...
Action
Avoid the combination when possible. If no alternative exists, correct electrolyte abnormalities, review other QT-prolon...
Frequently asked questions
Can I take Citalopram and Hydroxychloroquine together?
No — this combination should generally be avoided. Avoid the combination when possible. If no alternative exists, correct electrolyte abnormalities, review other QT-prolonging drugs, and obtain baseline and follow-up ECGs.
What is the severity of this interaction?
The interaction between Citalopram and Hydroxychloroquine is classified as Major — avoid combination. Both drugs inhibit cardiac potassium currents involved in repolarization and can prolong the QT interval. Their combined use increases the risk of torsades de pointes and sudden cardiac death.
What should I do if I'm prescribed both?
Avoid the combination when possible. If no alternative exists, correct electrolyte abnormalities, review other QT-prolonging drugs, and obtain baseline and follow-up ECGs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.