Citalopram and Erythromycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Erythromycin unless specifically directed by your doctor.
How Citalopram interacts with Erythromycin
Both drugs prolong cardiac repolarization through potassium-channel effects, producing additive QT prolongation and an increased risk of torsades de pointes.
What you should do
Avoid concurrent use and choose a non-QT-prolonging antibiotic when possible. If exceptional use is unavoidable, correct electrolytes and obtain ECG monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs prolong cardiac repolarization through potassium-channel effects, producing additive QT prolongation and an i...
Action
Avoid concurrent use and choose a non-QT-prolonging antibiotic when possible. If exceptional use is unavoidable, correct...
Frequently asked questions
Can I take Citalopram and Erythromycin together?
No — this combination should generally be avoided. Avoid concurrent use and choose a non-QT-prolonging antibiotic when possible. If exceptional use is unavoidable, correct electrolytes and obtain ECG monitoring.
What is the severity of this interaction?
The interaction between Citalopram and Erythromycin is classified as Major — avoid combination. Both drugs prolong cardiac repolarization through potassium-channel effects, producing additive QT prolongation and an increased risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid concurrent use and choose a non-QT-prolonging antibiotic when possible. If exceptional use is unavoidable, correct electrolytes and obtain ECG monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.