Citalopram and Domperidone: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Citalopram and Domperidone unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Citalopram interacts with Domperidone

Both drugs can prolong cardiac repolarization through effects on hERG potassium channels. Combined use increases QT prolongation and torsades de pointes risk.

What you should do

Avoid coadministration where possible. If essential, assess ECG, electrolytes, cardiac history, and use the lowest effective doses.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs can prolong cardiac repolarization through effects on hERG potassium channels. Combined use increases QT prol...

Action

Avoid coadministration where possible. If essential, assess ECG, electrolytes, cardiac history, and use the lowest effec...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Citalopram and Domperidone together?

No — this combination should generally be avoided. Avoid coadministration where possible. If essential, assess ECG, electrolytes, cardiac history, and use the lowest effective doses.

What is the severity of this interaction?

The interaction between Citalopram and Domperidone is classified as Major — avoid combination. Both drugs can prolong cardiac repolarization through effects on hERG potassium channels. Combined use increases QT prolongation and torsades de pointes risk.

What should I do if I'm prescribed both?

Avoid coadministration where possible. If essential, assess ECG, electrolytes, cardiac history, and use the lowest effective doses. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.