Cimetidine and Diazepam: Drug Interaction Guide

Quick answer: Cimetidine and Diazepam have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Cimetidine interacts with Diazepam

Cimetidine inhibits hepatic CYP enzymes involved in diazepam clearance, potentially increasing diazepam exposure and prolonging sedation.

What you should do

Monitor for excessive sedation, especially in older adults, and consider famotidine or a benzodiazepine primarily cleared by glucuronidation.

Key facts

Severity

Minor — typically manageable

Mechanism

Cimetidine inhibits hepatic CYP enzymes involved in diazepam clearance, potentially increasing diazepam exposure and pro...

Action

Monitor for excessive sedation, especially in older adults, and consider famotidine or a benzodiazepine primarily cleare...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cimetidine and Diazepam together?

Usually yes, with awareness. Monitor for excessive sedation, especially in older adults, and consider famotidine or a benzodiazepine primarily cleared by glucuronidation.

What is the severity of this interaction?

The interaction between Cimetidine and Diazepam is classified as Minor — typically manageable. Cimetidine inhibits hepatic CYP enzymes involved in diazepam clearance, potentially increasing diazepam exposure and prolonging sedation.

What should I do if I'm prescribed both?

Monitor for excessive sedation, especially in older adults, and consider famotidine or a benzodiazepine primarily cleared by glucuronidation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.