Ciclosporin and Gentamicin: Drug Interaction Guide

Quick answer: This combination requires caution. Ciclosporin and Gentamicin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ciclosporin interacts with Gentamicin

Ciclosporin and gentamicin both have nephrotoxic potential through renal tubular and hemodynamic injury. Combined exposure increases the risk of acute kidney injury.

What you should do

Avoid prolonged combination where possible. Monitor renal function closely and use therapeutic drug monitoring for gentamicin and ciclosporin.

Key facts

Severity

Moderate — caution required

Mechanism

Ciclosporin and gentamicin both have nephrotoxic potential through renal tubular and hemodynamic injury. Combined exposu...

Action

Avoid prolonged combination where possible. Monitor renal function closely and use therapeutic drug monitoring for genta...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Gentamicin together?

With caution. Avoid prolonged combination where possible. Monitor renal function closely and use therapeutic drug monitoring for gentamicin and ciclosporin.

What is the severity of this interaction?

The interaction between Ciclosporin and Gentamicin is classified as Moderate — caution required. Ciclosporin and gentamicin both have nephrotoxic potential through renal tubular and hemodynamic injury. Combined exposure increases the risk of acute kidney injury.

What should I do if I'm prescribed both?

Avoid prolonged combination where possible. Monitor renal function closely and use therapeutic drug monitoring for gentamicin and ciclosporin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.