Ciclosporin and Erythromycin: Drug Interaction Guide
Quick answer: This combination requires caution. Ciclosporin and Erythromycin can be used together with adjustments and monitoring.
How Ciclosporin interacts with Erythromycin
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin exposure and nephrotoxicity risk.
What you should do
Use an alternative antibiotic if possible; monitor ciclosporin trough concentrations, renal function, and blood pressure if co-administered.
Key facts
Severity
Moderate — caution required
Mechanism
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin exposure and nephrotoxicity risk.
Action
Use an alternative antibiotic if possible; monitor ciclosporin trough concentrations, renal function, and blood pressure...
Frequently asked questions
Can I take Ciclosporin and Erythromycin together?
With caution. Use an alternative antibiotic if possible; monitor ciclosporin trough concentrations, renal function, and blood pressure if co-administered.
What is the severity of this interaction?
The interaction between Ciclosporin and Erythromycin is classified as Moderate — caution required. Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing ciclosporin exposure and nephrotoxicity risk.
What should I do if I'm prescribed both?
Use an alternative antibiotic if possible; monitor ciclosporin trough concentrations, renal function, and blood pressure if co-administered. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.