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Ciclosporin and Diltiazem: Drug Interaction Guide

Quick answer: This combination requires caution. Ciclosporin and Diltiazem can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Ciclosporin interacts with Diltiazem

Diltiazem inhibits CYP3A4 and P-glycoprotein, reducing ciclosporin metabolism and efflux, which increases ciclosporin trough levels and nephrotoxicity risk.

What you should do

Monitor ciclosporin trough levels closely after initiating diltiazem; expect to reduce ciclosporin dose by approximately 25-40%.

Key facts

Severity

Moderate — caution required

Mechanism

Diltiazem inhibits CYP3A4 and P-glycoprotein, reducing ciclosporin metabolism and efflux, which increases ciclosporin tr...

Action

Monitor ciclosporin trough levels closely after initiating diltiazem; expect to reduce ciclosporin dose by approximately...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Diltiazem together?

With caution. Monitor ciclosporin trough levels closely after initiating diltiazem; expect to reduce ciclosporin dose by approximately 25-40%.

What is the severity of this interaction?

The interaction between Ciclosporin and Diltiazem is classified as Moderate — caution required. Diltiazem inhibits CYP3A4 and P-glycoprotein, reducing ciclosporin metabolism and efflux, which increases ciclosporin trough levels and nephrotoxicity risk.

What should I do if I'm prescribed both?

Monitor ciclosporin trough levels closely after initiating diltiazem; expect to reduce ciclosporin dose by approximately 25-40%. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.