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Diltiazem and Tacrolimus: Drug Interaction Guide

Quick answer: This combination requires caution. Diltiazem and Tacrolimus can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diltiazem interacts with Tacrolimus

Diltiazem inhibits CYP3A4 metabolism of tacrolimus, raising blood concentrations and the risk of nephrotoxicity and tremor.

What you should do

Reduce tacrolimus dose by approximately one-third on initiation and monitor trough levels weekly until stable.

Key facts

Severity

Moderate — caution required

Mechanism

Diltiazem inhibits CYP3A4 metabolism of tacrolimus, raising blood concentrations and the risk of nephrotoxicity and trem...

Action

Reduce tacrolimus dose by approximately one-third on initiation and monitor trough levels weekly until stable.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diltiazem and Tacrolimus together?

With caution. Reduce tacrolimus dose by approximately one-third on initiation and monitor trough levels weekly until stable.

What is the severity of this interaction?

The interaction between Diltiazem and Tacrolimus is classified as Moderate — caution required. Diltiazem inhibits CYP3A4 metabolism of tacrolimus, raising blood concentrations and the risk of nephrotoxicity and tremor.

What should I do if I'm prescribed both?

Reduce tacrolimus dose by approximately one-third on initiation and monitor trough levels weekly until stable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.