Cholestyramine and Hydrochlorothiazide: Drug Interaction Guide

Quick answer: Cholestyramine and Hydrochlorothiazide have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Cholestyramine interacts with Hydrochlorothiazide

Cholestyramine can bind hydrochlorothiazide in the gastrointestinal tract and reduce its absorption and therapeutic effect.

What you should do

Administer hydrochlorothiazide at least 1 hour before or 4 to 6 hours after cholestyramine and monitor blood pressure.

Key facts

Severity

Minor — typically manageable

Mechanism

Cholestyramine can bind hydrochlorothiazide in the gastrointestinal tract and reduce its absorption and therapeutic effe...

Action

Administer hydrochlorothiazide at least 1 hour before or 4 to 6 hours after cholestyramine and monitor blood pressure.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cholestyramine and Hydrochlorothiazide together?

Usually yes, with awareness. Administer hydrochlorothiazide at least 1 hour before or 4 to 6 hours after cholestyramine and monitor blood pressure.

What is the severity of this interaction?

The interaction between Cholestyramine and Hydrochlorothiazide is classified as Minor — typically manageable. Cholestyramine can bind hydrochlorothiazide in the gastrointestinal tract and reduce its absorption and therapeutic effect.

What should I do if I'm prescribed both?

Administer hydrochlorothiazide at least 1 hour before or 4 to 6 hours after cholestyramine and monitor blood pressure. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.