Fluconazole and Hydrochlorothiazide: Drug Interaction Guide
Quick answer: Fluconazole and Hydrochlorothiazide have a minor interaction — typically manageable with awareness.
How Fluconazole interacts with Hydrochlorothiazide
Hydrochlorothiazide reduces renal clearance of fluconazole and can modestly increase its plasma concentration.
What you should do
Dose adjustment is generally unnecessary, but monitor for fluconazole adverse effects during prolonged therapy or in patients with renal impairment.
Key facts
Severity
Minor — typically manageable
Mechanism
Hydrochlorothiazide reduces renal clearance of fluconazole and can modestly increase its plasma concentration.
Action
Dose adjustment is generally unnecessary, but monitor for fluconazole adverse effects during prolonged therapy or in pat...
Frequently asked questions
Can I take Fluconazole and Hydrochlorothiazide together?
Usually yes, with awareness. Dose adjustment is generally unnecessary, but monitor for fluconazole adverse effects during prolonged therapy or in patients with renal impairment.
What is the severity of this interaction?
The interaction between Fluconazole and Hydrochlorothiazide is classified as Minor — typically manageable. Hydrochlorothiazide reduces renal clearance of fluconazole and can modestly increase its plasma concentration.
What should I do if I'm prescribed both?
Dose adjustment is generally unnecessary, but monitor for fluconazole adverse effects during prolonged therapy or in patients with renal impairment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.