Cholecalciferol and Hydrochlorothiazide: Drug Interaction Guide
Quick answer: Cholecalciferol and Hydrochlorothiazide have a minor interaction — typically manageable with awareness.
How Cholecalciferol interacts with Hydrochlorothiazide
Cholecalciferol increases intestinal calcium absorption, while hydrochlorothiazide reduces renal calcium excretion, modestly increasing the risk of hypercalcaemia.
What you should do
Usual replacement doses are generally acceptable, but monitor serum calcium when high vitamin D doses are used or in patients with renal impairment or hyperparathyroidism.
Key facts
Severity
Minor — typically manageable
Mechanism
Cholecalciferol increases intestinal calcium absorption, while hydrochlorothiazide reduces renal calcium excretion, mode...
Action
Usual replacement doses are generally acceptable, but monitor serum calcium when high vitamin D doses are used or in pat...
Frequently asked questions
Can I take Cholecalciferol and Hydrochlorothiazide together?
Usually yes, with awareness. Usual replacement doses are generally acceptable, but monitor serum calcium when high vitamin D doses are used or in patients with renal impairment or hyperparathyroidism.
What is the severity of this interaction?
The interaction between Cholecalciferol and Hydrochlorothiazide is classified as Minor — typically manageable. Cholecalciferol increases intestinal calcium absorption, while hydrochlorothiazide reduces renal calcium excretion, modestly increasing the risk of hypercalcaemia.
What should I do if I'm prescribed both?
Usual replacement doses are generally acceptable, but monitor serum calcium when high vitamin D doses are used or in patients with renal impairment or hyperparathyroidism. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.