Chloramphenicol and Tolbutamide: Drug Interaction Guide

Quick answer: This combination requires caution. Chloramphenicol and Tolbutamide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Chloramphenicol interacts with Tolbutamide

Chloramphenicol inhibits hepatic metabolism of sulfonylureas such as tolbutamide. Increased sulfonylurea exposure can cause hypoglycemia.

What you should do

Monitor blood glucose closely and reduce sulfonylurea dose if needed; consider an alternative antibiotic.

Key facts

Severity

Moderate — caution required

Mechanism

Chloramphenicol inhibits hepatic metabolism of sulfonylureas such as tolbutamide. Increased sulfonylurea exposure can ca...

Action

Monitor blood glucose closely and reduce sulfonylurea dose if needed; consider an alternative antibiotic.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Chloramphenicol and Tolbutamide together?

With caution. Monitor blood glucose closely and reduce sulfonylurea dose if needed; consider an alternative antibiotic.

What is the severity of this interaction?

The interaction between Chloramphenicol and Tolbutamide is classified as Moderate — caution required. Chloramphenicol inhibits hepatic metabolism of sulfonylureas such as tolbutamide. Increased sulfonylurea exposure can cause hypoglycemia.

What should I do if I'm prescribed both?

Monitor blood glucose closely and reduce sulfonylurea dose if needed; consider an alternative antibiotic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.