Caffeine and Theophylline: Drug Interaction Guide

Quick answer: This combination requires caution. Caffeine and Theophylline can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Caffeine interacts with Theophylline

Both substances are methylxanthines with additive adenosine-receptor antagonism and phosphodiesterase inhibition; competition involving CYP1A2 may also increase stimulant effects.

What you should do

Limit high caffeine intake and monitor for tremor, insomnia, tachycardia, nausea, or seizures. Measure theophylline concentrations when toxicity is suspected.

Key facts

Severity

Moderate — caution required

Mechanism

Both substances are methylxanthines with additive adenosine-receptor antagonism and phosphodiesterase inhibition; compet...

Action

Limit high caffeine intake and monitor for tremor, insomnia, tachycardia, nausea, or seizures. Measure theophylline conc...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Caffeine and Theophylline together?

With caution. Limit high caffeine intake and monitor for tremor, insomnia, tachycardia, nausea, or seizures. Measure theophylline concentrations when toxicity is suspected.

What is the severity of this interaction?

The interaction between Caffeine and Theophylline is classified as Moderate — caution required. Both substances are methylxanthines with additive adenosine-receptor antagonism and phosphodiesterase inhibition; competition involving CYP1A2 may also increase stimulant effects.

What should I do if I'm prescribed both?

Limit high caffeine intake and monitor for tremor, insomnia, tachycardia, nausea, or seizures. Measure theophylline concentrations when toxicity is suspected. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.