Caffeine and Fluvoxamine: Drug Interaction Guide

Quick answer: This combination requires caution. Caffeine and Fluvoxamine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Caffeine interacts with Fluvoxamine

Fluvoxamine strongly inhibits CYP1A2, markedly reducing caffeine clearance and increasing stimulant-related adverse effects.

What you should do

Advise a substantial reduction in caffeine intake and monitor for insomnia, tremor, palpitations, agitation, and nausea.

Key facts

Severity

Moderate — caution required

Mechanism

Fluvoxamine strongly inhibits CYP1A2, markedly reducing caffeine clearance and increasing stimulant-related adverse effe...

Action

Advise a substantial reduction in caffeine intake and monitor for insomnia, tremor, palpitations, agitation, and nausea.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Caffeine and Fluvoxamine together?

With caution. Advise a substantial reduction in caffeine intake and monitor for insomnia, tremor, palpitations, agitation, and nausea.

What is the severity of this interaction?

The interaction between Caffeine and Fluvoxamine is classified as Moderate — caution required. Fluvoxamine strongly inhibits CYP1A2, markedly reducing caffeine clearance and increasing stimulant-related adverse effects.

What should I do if I'm prescribed both?

Advise a substantial reduction in caffeine intake and monitor for insomnia, tremor, palpitations, agitation, and nausea. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.