Bupropion and Codeine: Drug Interaction Guide

Quick answer: This combination requires caution. Bupropion and Codeine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Bupropion interacts with Codeine

Bupropion strongly inhibits CYP2D6, reducing conversion of codeine to its active metabolite morphine and potentially decreasing analgesia.

What you should do

Monitor pain control and use an analgesic that does not depend on CYP2D6 activation if efficacy is inadequate.

Key facts

Severity

Moderate — caution required

Mechanism

Bupropion strongly inhibits CYP2D6, reducing conversion of codeine to its active metabolite morphine and potentially dec...

Action

Monitor pain control and use an analgesic that does not depend on CYP2D6 activation if efficacy is inadequate.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Bupropion and Codeine together?

With caution. Monitor pain control and use an analgesic that does not depend on CYP2D6 activation if efficacy is inadequate.

What is the severity of this interaction?

The interaction between Bupropion and Codeine is classified as Moderate — caution required. Bupropion strongly inhibits CYP2D6, reducing conversion of codeine to its active metabolite morphine and potentially decreasing analgesia.

What should I do if I'm prescribed both?

Monitor pain control and use an analgesic that does not depend on CYP2D6 activation if efficacy is inadequate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.