Bupropion and Tramadol: Drug Interaction Guide

Quick answer: This combination requires caution. Bupropion and Tramadol can be used together with adjustments and monitoring.

How Bupropion interacts with Tramadol

Bupropion inhibits CYP2D6, which can reduce formation of tramadol's active opioid metabolite while both agents lower seizure threshold. This may reduce analgesia and increase seizure risk.

What you should do

Avoid in patients at seizure risk and consider a non-serotonergic, non-CYP2D6-dependent analgesic.

Key facts

Severity

Moderate — caution required

Mechanism

Bupropion inhibits CYP2D6, which can reduce formation of tramadol's active opioid metabolite while both agents lower sei...

Action

Avoid in patients at seizure risk and consider a non-serotonergic, non-CYP2D6-dependent analgesic.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Bupropion and Tramadol together?

With caution. Avoid in patients at seizure risk and consider a non-serotonergic, non-CYP2D6-dependent analgesic.

What is the severity of this interaction?

The interaction between Bupropion and Tramadol is classified as Moderate — caution required. Bupropion inhibits CYP2D6, which can reduce formation of tramadol's active opioid metabolite while both agents lower seizure threshold. This may reduce analgesia and increase seizure risk.

What should I do if I'm prescribed both?

Avoid in patients at seizure risk and consider a non-serotonergic, non-CYP2D6-dependent analgesic. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: June 30, 2026 by iMedic Medical Editorial Team. Our editorial process.