Brivudine and Fluorouracil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Brivudine and Fluorouracil unless specifically directed by your doctor.
How Brivudine interacts with Fluorouracil
A brivudine metabolite irreversibly inhibits dihydropyrimidine dehydrogenase, preventing fluorouracil catabolism and causing potentially fatal fluoropyrimidine toxicity.
What you should do
The combination is contraindicated. Allow at least four weeks between brivudine treatment and administration of fluorouracil or another fluoropyrimidine.
Key facts
Severity
Major — avoid combination
Mechanism
A brivudine metabolite irreversibly inhibits dihydropyrimidine dehydrogenase, preventing fluorouracil catabolism and cau...
Action
The combination is contraindicated. Allow at least four weeks between brivudine treatment and administration of fluorour...
Frequently asked questions
Can I take Brivudine and Fluorouracil together?
No — this combination should generally be avoided. The combination is contraindicated. Allow at least four weeks between brivudine treatment and administration of fluorouracil or another fluoropyrimidine.
What is the severity of this interaction?
The interaction between Brivudine and Fluorouracil is classified as Major — avoid combination. A brivudine metabolite irreversibly inhibits dihydropyrimidine dehydrogenase, preventing fluorouracil catabolism and causing potentially fatal fluoropyrimidine toxicity.
What should I do if I'm prescribed both?
The combination is contraindicated. Allow at least four weeks between brivudine treatment and administration of fluorouracil or another fluoropyrimidine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.