Apixaban and Phenytoin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Phenytoin unless specifically directed by your doctor.
How Apixaban interacts with Phenytoin
Phenytoin strongly induces CYP3A4 and P-glycoprotein, accelerating apixaban metabolism and transport. Apixaban exposure may fall substantially, increasing thromboembolic risk.
What you should do
Avoid concurrent use. Select a non-inducing antiseizure medicine or an anticoagulant whose effect can be reliably monitored.
Key facts
Severity
Major — avoid combination
Mechanism
Phenytoin strongly induces CYP3A4 and P-glycoprotein, accelerating apixaban metabolism and transport. Apixaban exposure ...
Action
Avoid concurrent use. Select a non-inducing antiseizure medicine or an anticoagulant whose effect can be reliably monito...
Frequently asked questions
Can I take Apixaban and Phenytoin together?
No — this combination should generally be avoided. Avoid concurrent use. Select a non-inducing antiseizure medicine or an anticoagulant whose effect can be reliably monitored.
What is the severity of this interaction?
The interaction between Apixaban and Phenytoin is classified as Major — avoid combination. Phenytoin strongly induces CYP3A4 and P-glycoprotein, accelerating apixaban metabolism and transport. Apixaban exposure may fall substantially, increasing thromboembolic risk.
What should I do if I'm prescribed both?
Avoid concurrent use. Select a non-inducing antiseizure medicine or an anticoagulant whose effect can be reliably monitored. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.