Amoxicillin Clavulanic Acid and Warfarin: Drug Interaction Guide

Quick answer: This combination requires caution. Amoxicillin Clavulanic Acid and Warfarin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amoxicillin Clavulanic Acid interacts with Warfarin

Broad-spectrum antibiotic therapy may reduce intestinal vitamin K production, while infection and inflammation can further increase sensitivity to warfarin.

What you should do

Check the INR shortly after starting or stopping the antibiotic and adjust warfarin if necessary. Monitor for bleeding.

Key facts

Severity

Moderate — caution required

Mechanism

Broad-spectrum antibiotic therapy may reduce intestinal vitamin K production, while infection and inflammation can furth...

Action

Check the INR shortly after starting or stopping the antibiotic and adjust warfarin if necessary. Monitor for bleeding.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amoxicillin Clavulanic Acid and Warfarin together?

With caution. Check the INR shortly after starting or stopping the antibiotic and adjust warfarin if necessary. Monitor for bleeding.

What is the severity of this interaction?

The interaction between Amoxicillin Clavulanic Acid and Warfarin is classified as Moderate — caution required. Broad-spectrum antibiotic therapy may reduce intestinal vitamin K production, while infection and inflammation can further increase sensitivity to warfarin.

What should I do if I'm prescribed both?

Check the INR shortly after starting or stopping the antibiotic and adjust warfarin if necessary. Monitor for bleeding. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.