iMedic.health

Amlodipine and Simvastatin: Drug Interaction Guide

Quick answer: This combination requires caution. Amlodipine and Simvastatin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amlodipine interacts with Simvastatin

Amlodipine inhibits CYP3A4, increasing simvastatin levels and risk of myopathy/rhabdomyolysis.

What you should do

Limit simvastatin to maximum 20 mg daily when combined with amlodipine.

Key facts

Severity

Moderate — caution required

Mechanism

Amlodipine inhibits CYP3A4, increasing simvastatin levels and risk of myopathy/rhabdomyolysis.

Action

Limit simvastatin to maximum 20 mg daily when combined with amlodipine.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Simvastatin together?

With caution. Limit simvastatin to maximum 20 mg daily when combined with amlodipine.

What is the severity of this interaction?

The interaction between Amlodipine and Simvastatin is classified as Moderate — caution required. Amlodipine inhibits CYP3A4, increasing simvastatin levels and risk of myopathy/rhabdomyolysis.

What should I do if I'm prescribed both?

Limit simvastatin to maximum 20 mg daily when combined with amlodipine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.