Quinidine and Simvastatin: Drug Interaction Guide
Quick answer: This combination requires caution. Quinidine and Simvastatin can be used together with adjustments and monitoring.
How Quinidine interacts with Simvastatin
Quinidine inhibits CYP3A4 and P-glycoprotein to a clinically variable degree, which may increase simvastatin exposure and myopathy risk.
What you should do
Use the lowest effective simvastatin dose or choose a statin with less CYP3A4 dependence; monitor for muscle pain or weakness.
Key facts
Severity
Moderate — caution required
Mechanism
Quinidine inhibits CYP3A4 and P-glycoprotein to a clinically variable degree, which may increase simvastatin exposure an...
Action
Use the lowest effective simvastatin dose or choose a statin with less CYP3A4 dependence; monitor for muscle pain or wea...
Frequently asked questions
Can I take Quinidine and Simvastatin together?
With caution. Use the lowest effective simvastatin dose or choose a statin with less CYP3A4 dependence; monitor for muscle pain or weakness.
What is the severity of this interaction?
The interaction between Quinidine and Simvastatin is classified as Moderate — caution required. Quinidine inhibits CYP3A4 and P-glycoprotein to a clinically variable degree, which may increase simvastatin exposure and myopathy risk.
What should I do if I'm prescribed both?
Use the lowest effective simvastatin dose or choose a statin with less CYP3A4 dependence; monitor for muscle pain or weakness. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.