Amlodipine and Lisinopril: Drug Interaction Guide
Quick answer: Amlodipine and Lisinopril have a minor interaction — typically manageable with awareness.
How Amlodipine interacts with Lisinopril
L-type calcium-channel blockade and inhibition of the renin-angiotensin-aldosterone system produce additive vasodilation and blood-pressure reduction.
What you should do
The combination is commonly appropriate, but monitor blood pressure and symptoms of dizziness or orthostatic hypotension after initiation or dose escalation.
Key facts
Severity
Minor — typically manageable
Mechanism
L-type calcium-channel blockade and inhibition of the renin-angiotensin-aldosterone system produce additive vasodilation...
Action
The combination is commonly appropriate, but monitor blood pressure and symptoms of dizziness or orthostatic hypotension...
Frequently asked questions
Can I take Amlodipine and Lisinopril together?
Usually yes, with awareness. The combination is commonly appropriate, but monitor blood pressure and symptoms of dizziness or orthostatic hypotension after initiation or dose escalation.
What is the severity of this interaction?
The interaction between Amlodipine and Lisinopril is classified as Minor — typically manageable. L-type calcium-channel blockade and inhibition of the renin-angiotensin-aldosterone system produce additive vasodilation and blood-pressure reduction.
What should I do if I'm prescribed both?
The combination is commonly appropriate, but monitor blood pressure and symptoms of dizziness or orthostatic hypotension after initiation or dose escalation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.