Aspirin and Lisinopril: Drug Interaction Guide

Quick answer: Aspirin and Lisinopril have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Aspirin interacts with Lisinopril

Cyclooxygenase inhibition can reduce renal vasodilatory prostaglandins, potentially attenuating the antihypertensive effect of lisinopril and reducing renal perfusion. This effect is generally limited with low-dose aspirin.

What you should do

Low-dose antiplatelet aspirin can usually be continued. Monitor blood pressure, renal function, and potassium in susceptible patients or when higher aspirin doses are used.

Key facts

Severity

Minor — typically manageable

Mechanism

Cyclooxygenase inhibition can reduce renal vasodilatory prostaglandins, potentially attenuating the antihypertensive eff...

Action

Low-dose antiplatelet aspirin can usually be continued. Monitor blood pressure, renal function, and potassium in suscept...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aspirin and Lisinopril together?

Usually yes, with awareness. Low-dose antiplatelet aspirin can usually be continued. Monitor blood pressure, renal function, and potassium in susceptible patients or when higher aspirin doses are used.

What is the severity of this interaction?

The interaction between Aspirin and Lisinopril is classified as Minor — typically manageable. Cyclooxygenase inhibition can reduce renal vasodilatory prostaglandins, potentially attenuating the antihypertensive effect of lisinopril and reducing renal perfusion. This effect is generally limited with low-dose aspirin.

What should I do if I'm prescribed both?

Low-dose antiplatelet aspirin can usually be continued. Monitor blood pressure, renal function, and potassium in susceptible patients or when higher aspirin doses are used. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.