Amlodipine and Isosorbide Mononitrate: Drug Interaction Guide

Quick answer: Amlodipine and Isosorbide Mononitrate have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Amlodipine interacts with Isosorbide Mononitrate

Arterial vasodilation from amlodipine and venous vasodilation from isosorbide mononitrate can produce additive blood-pressure reduction.

What you should do

Monitor blood pressure and orthostatic symptoms during initiation and titration. Advise patients to rise slowly and report troublesome dizziness or syncope.

Key facts

Severity

Minor — typically manageable

Mechanism

Arterial vasodilation from amlodipine and venous vasodilation from isosorbide mononitrate can produce additive blood-pre...

Action

Monitor blood pressure and orthostatic symptoms during initiation and titration. Advise patients to rise slowly and repo...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Isosorbide Mononitrate together?

Usually yes, with awareness. Monitor blood pressure and orthostatic symptoms during initiation and titration. Advise patients to rise slowly and report troublesome dizziness or syncope.

What is the severity of this interaction?

The interaction between Amlodipine and Isosorbide Mononitrate is classified as Minor — typically manageable. Arterial vasodilation from amlodipine and venous vasodilation from isosorbide mononitrate can produce additive blood-pressure reduction.

What should I do if I'm prescribed both?

Monitor blood pressure and orthostatic symptoms during initiation and titration. Advise patients to rise slowly and report troublesome dizziness or syncope. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.