Acenocoumarol and Metronidazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Acenocoumarol and Metronidazole unless specifically directed by your doctor.
How Acenocoumarol interacts with Metronidazole
Metronidazole inhibits CYP2C9-mediated metabolism of coumarin anticoagulants. This increases anticoagulant effect and bleeding risk.
What you should do
Avoid if possible or reduce anticoagulant dose and monitor INR frequently during and after metronidazole therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Metronidazole inhibits CYP2C9-mediated metabolism of coumarin anticoagulants. This increases anticoagulant effect and bl...
Action
Avoid if possible or reduce anticoagulant dose and monitor INR frequently during and after metronidazole therapy.
Frequently asked questions
Can I take Acenocoumarol and Metronidazole together?
No — this combination should generally be avoided. Avoid if possible or reduce anticoagulant dose and monitor INR frequently during and after metronidazole therapy.
What is the severity of this interaction?
The interaction between Acenocoumarol and Metronidazole is classified as Major — avoid combination. Metronidazole inhibits CYP2C9-mediated metabolism of coumarin anticoagulants. This increases anticoagulant effect and bleeding risk.
What should I do if I'm prescribed both?
Avoid if possible or reduce anticoagulant dose and monitor INR frequently during and after metronidazole therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.