Abemaciclib and Clarithromycin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Abemaciclib and Clarithromycin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Abemaciclib interacts with Clarithromycin

Clarithromycin strongly inhibits CYP3A4, the principal pathway for abemaciclib metabolism, substantially increasing abemaciclib exposure and toxicity risk.

What you should do

Avoid the combination and select a non-inhibiting antibiotic. If unavoidable, interrupt or markedly reduce abemaciclib according to its prescribing information and monitor closely for diarrhoea, neutropenia, and hepatotoxicity.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin strongly inhibits CYP3A4, the principal pathway for abemaciclib metabolism, substantially increasing abem...

Action

Avoid the combination and select a non-inhibiting antibiotic. If unavoidable, interrupt or markedly reduce abemaciclib a...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Abemaciclib and Clarithromycin together?

No — this combination should generally be avoided. Avoid the combination and select a non-inhibiting antibiotic. If unavoidable, interrupt or markedly reduce abemaciclib according to its prescribing information and monitor closely for diarrhoea, neutropenia, and hepatotoxicity.

What is the severity of this interaction?

The interaction between Abemaciclib and Clarithromycin is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, the principal pathway for abemaciclib metabolism, substantially increasing abemaciclib exposure and toxicity risk.

What should I do if I'm prescribed both?

Avoid the combination and select a non-inhibiting antibiotic. If unavoidable, interrupt or markedly reduce abemaciclib according to its prescribing information and monitor closely for diarrhoea, neutropenia, and hepatotoxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.