Withdrawal Method: Effectiveness, Risks & How It Works

Medically reviewed | Last reviewed: | Evidence level: 1A
The withdrawal method (coitus interruptus or "pulling out") is one of the oldest forms of birth control, where the penis is withdrawn from the vagina before ejaculation. While it provides some protection against pregnancy, it has a typical-use failure rate of approximately 20% per year, making it one of the less reliable contraceptive methods. It provides no protection against sexually transmitted infections (STIs).
📅 Updated:
⏱️ Reading time: 12 minutes
Written and reviewed by iMedic Medical Editorial Team | Specialists in reproductive health

📊 Quick facts about the withdrawal method

Typical-use failure rate
~20%
per year
Perfect-use failure rate
~4%
per year
STI protection
None
use condoms for STIs
Pre-ejaculate risk
16-41%
may contain sperm
Cost
Free
no supplies needed
ICD-10 code
Z30.09
contraception counseling

💡 The most important things you need to know

  • High failure rate: About 1 in 5 couples using withdrawal will experience pregnancy within one year (20% typical-use failure rate)
  • Pre-ejaculate can contain sperm: Research shows 16-41% of men have sperm in their pre-ejaculatory fluid
  • No STI protection: The withdrawal method provides zero protection against sexually transmitted infections
  • Requires perfect timing: Must withdraw completely before any ejaculation begins - difficult during arousal
  • Better than nothing: Still reduces pregnancy risk from 85% (no method) to approximately 20%
  • Emergency contraception exists: If withdrawal fails, emergency contraception is available within 5 days
  • Consider more reliable methods: IUDs, implants, and hormonal contraceptives are 91-99% effective

What Is the Withdrawal Method?

The withdrawal method, also known as coitus interruptus or "pulling out," is a contraceptive technique where the penis is completely withdrawn from the vagina before ejaculation occurs. This ancient method aims to prevent sperm from entering the vagina and reaching the egg. While free and always available, it has significant limitations including a 20% typical-use failure rate and no protection against sexually transmitted infections.

The withdrawal method is one of the oldest documented forms of birth control, with references dating back thousands of years in various cultures and religious texts. Despite the development of many more reliable contraceptive methods over the past century, withdrawal remains widely used globally. According to the World Health Organization, approximately 3% of couples worldwide rely on withdrawal as their primary contraceptive method, with much higher rates in certain regions.

The fundamental principle behind the withdrawal method is straightforward: by removing the penis from the vagina before ejaculation, sperm-containing semen is prevented from entering the female reproductive tract. When semen is deposited outside the body, sperm cannot travel through the cervix, uterus, and fallopian tubes to potentially fertilize an egg. In theory, this should prevent pregnancy entirely. However, the practical application of this method presents numerous challenges that significantly reduce its real-world effectiveness.

Understanding why this method exists and continues to be used requires acknowledging its unique characteristics. Unlike hormonal methods, it has no side effects. Unlike barrier methods, it requires no supplies or advance planning. Unlike surgical sterilization, it is completely reversible. These factors make it an appealing option for some couples, despite its lower effectiveness compared to other contraceptive methods.

Historical Context and Cultural Significance

Throughout human history, the withdrawal method has been documented across numerous civilizations. Ancient texts from various cultures reference this practice, and it was often the only available method of fertility control before modern contraception. In many societies, it remained the primary method of family planning well into the 20th century. Even today, cultural, religious, or personal beliefs may lead individuals to choose withdrawal over other methods, making comprehensive education about its effectiveness and limitations particularly important.

Medical Classification

In medical terminology, the withdrawal method is classified as a behavioral contraceptive method. Unlike barrier methods (condoms, diaphragms), hormonal methods (pills, injections, implants), or intrauterine devices (IUDs), behavioral methods rely entirely on human action and timing rather than physical barriers or hormonal changes. Other behavioral methods include fertility awareness-based methods (tracking ovulation) and abstinence. The withdrawal method's classification helps explain both its accessibility and its limitations.

How Effective Is the Withdrawal Method?

The withdrawal method has a typical-use failure rate of approximately 20%, meaning about 1 in 5 couples using this method will experience pregnancy within one year. With perfect use (correct withdrawal every single time), the failure rate drops to about 4%. However, perfect use is difficult to achieve consistently, making this one of the least reliable contraceptive methods available.

Understanding contraceptive effectiveness requires distinguishing between two important measurements: perfect-use effectiveness and typical-use effectiveness. Perfect-use effectiveness assumes the method is used correctly and consistently every single time, without any errors. Typical-use effectiveness reflects how the method performs in real-world conditions, accounting for human error, inconsistent use, and other practical factors. For most contraceptive methods, there is a significant gap between these two figures, and this gap is particularly pronounced with the withdrawal method.

According to data from the World Health Organization and the Centers for Disease Control and Prevention, the withdrawal method demonstrates the following effectiveness rates:

Comparison of contraceptive method failure rates (pregnancies per 100 women per year)
Method Perfect Use Typical Use STI Protection
Withdrawal 4% 20% None
Male condom 2% 13% Yes
Combined pill 0.3% 7% None
Copper IUD 0.6% 0.8% None
Hormonal IUD 0.1% 0.1% None
Implant 0.1% 0.1% None
No method 85% 85% None

The substantial difference between perfect-use (4%) and typical-use (20%) failure rates for the withdrawal method highlights a critical point: this method depends entirely on human behavior in a moment of intense physical and emotional arousal. Factors that contribute to the gap include difficulty sensing when ejaculation is imminent, reduced self-control during arousal, miscommunication between partners, and the presence of sperm in pre-ejaculatory fluid.

Factors Affecting Effectiveness

Several factors influence how effective the withdrawal method is for a particular couple. Experience matters significantly - couples who have used this method for years typically develop better timing and communication. Age can also play a role, as younger men may have more difficulty predicting ejaculation. Relationship factors, including trust and communication between partners, directly impact consistent and correct use. Finally, alcohol or drug use can impair judgment and reduce the likelihood of successful withdrawal.

⚠️ Important perspective on failure rates

A 20% typical-use failure rate means that over one year, approximately 20 out of every 100 couples relying solely on withdrawal will experience a pregnancy. Over five years of use, the cumulative probability of pregnancy becomes significantly higher. Couples should carefully consider these statistics when choosing their contraceptive method.

Can You Get Pregnant from Pre-Ejaculate?

Yes, pregnancy from pre-ejaculate (pre-cum) is possible. Multiple studies have found that pre-ejaculatory fluid can contain sperm in some men, with estimates ranging from 16% to 41% of men having detectable sperm in their pre-ejaculate. While sperm concentrations are typically lower than in semen, pregnancy can still occur if sperm reach the vagina.

Pre-ejaculatory fluid, commonly called "pre-cum," is a clear, viscous fluid released from the penis during sexual arousal, before ejaculation occurs. This fluid is produced by the Cowper's glands (bulbourethral glands) and serves several physiological functions: it helps lubricate the urethra, neutralizes any residual acidity from urine in the urethra (creating a more sperm-friendly environment), and provides lubrication during intercourse.

The question of whether pre-ejaculate contains sperm has been studied extensively, with somewhat varying results. A landmark 2011 study published in Human Fertility examined pre-ejaculatory samples from 27 men and found that 41% had sperm present in their pre-ejaculate, with 37% having motile (actively swimming) sperm. A subsequent 2016 study in the Journal of Medical Association of Thailand found sperm in the pre-ejaculate of approximately 16.7% of healthy men studied.

The presence of sperm in pre-ejaculate appears to vary between individuals. Some men consistently have sperm in their pre-ejaculate, while others never do. The mechanism by which sperm enters pre-ejaculate is not entirely understood, but several theories exist. One prominent theory suggests that residual sperm from a previous ejaculation may remain in the urethra and become mixed with pre-ejaculatory fluid. This would explain why urinating between ejaculations might reduce (but not eliminate) the risk of sperm in pre-ejaculate.

Implications for the Withdrawal Method

The presence of sperm in pre-ejaculate has significant implications for withdrawal method users. Even if withdrawal is performed perfectly (complete removal of the penis before any ejaculation), sperm released during the pre-ejaculatory phase may already have entered the vagina. This represents an inherent limitation of the method that cannot be overcome through better technique or timing. It also means that even with perfect withdrawal, some pregnancy risk exists.

Reducing pre-ejaculate risks:

While not guaranteed to eliminate risk, urinating between ejaculations may help flush residual sperm from the urethra, potentially reducing the concentration of sperm in subsequent pre-ejaculate. However, this should not be relied upon as a reliable risk reduction strategy.

Why Is the Withdrawal Method Unreliable?

The withdrawal method is unreliable for multiple reasons: it requires perfect timing during intense arousal, pre-ejaculate may contain sperm, many men cannot reliably sense when ejaculation is about to occur, and even brief delays in withdrawal allow sperm to enter the vagina. Human error is virtually inevitable over repeated use, leading to the high typical-use failure rate of 20%.

Understanding why the withdrawal method fails so frequently requires examining the biological, psychological, and practical factors involved in its use. Unlike methods that create physical barriers or alter hormonal patterns, withdrawal depends entirely on conscious human action during one of the most physiologically and emotionally intense human experiences. This fundamental reliance on human behavior under challenging conditions is the primary source of its unreliability.

Biological Factors

The male sexual response involves a series of physiological stages leading to ejaculation. The sensation of impending ejaculation, while often identifiable, can be subtle and varies significantly between individuals and even between sexual encounters for the same individual. Factors such as arousal level, time since last ejaculation, alcohol consumption, and the specific circumstances of the encounter all influence how easily ejaculation can be predicted and controlled.

The ejaculatory reflex, once triggered, is largely involuntary. The point of "ejaculatory inevitability" - after which ejaculation cannot be stopped - occurs several seconds before ejaculation itself. If withdrawal is not initiated before this point, it cannot be successfully completed. The window of time for successful withdrawal may be measured in seconds, making split-second timing essential.

Psychological and Situational Factors

Sexual arousal involves significant changes in cognitive function, including reduced inhibition and altered decision-making capacity. During intense arousal, the prefrontal cortex (responsible for executive function and decision-making) shows reduced activity, while limbic system activity (associated with emotion and reward) increases. This neurological state can impair judgment and make it more difficult to execute the withdrawal method correctly.

Relationship dynamics also play a role. Trust and communication between partners are essential for consistent withdrawal. If one partner is uncertain about the other's commitment to withdrawal, or if communication during intercourse is poor, the likelihood of failure increases. Additionally, some individuals may experience ambivalence about pregnancy, consciously or unconsciously, which can affect their commitment to successful withdrawal.

The Cumulative Risk Problem

Perhaps the most important factor in withdrawal's unreliability is the cumulative nature of risk over time. Even if a couple successfully withdraws 95% of the time, the 5% failure rate compounds with each sexual encounter. A couple having intercourse 100 times per year with a 5% per-encounter failure rate faces a substantially higher annual pregnancy probability. This mathematical reality explains why typical-use failure rates are so much higher than what many users might intuitively expect.

Does the Withdrawal Method Protect Against STIs?

No, the withdrawal method provides absolutely no protection against sexually transmitted infections (STIs). STIs can be transmitted through pre-ejaculatory fluid, vaginal secretions, skin-to-skin contact, and mucous membrane contact - all of which occur during intercourse before withdrawal. Only barrier methods like condoms provide STI protection.

Sexually transmitted infections represent a critical health concern that the withdrawal method does not address in any way. Many people conflate pregnancy prevention with STI prevention, but these are entirely separate considerations. While some contraceptive methods (notably condoms) provide both pregnancy prevention and STI risk reduction, the withdrawal method provides only the former, and even that with limited effectiveness.

The transmission mechanisms of various STIs occur throughout sexual contact, not just at ejaculation. HIV, for example, can be present in pre-ejaculatory fluid as well as vaginal secretions. Herpes simplex virus (HSV) and human papillomavirus (HPV) are transmitted primarily through skin-to-skin contact, which occurs throughout intercourse regardless of whether withdrawal is performed. Chlamydia and gonorrhea can be transmitted through infected secretions, including pre-ejaculate and vaginal fluids exchanged during intercourse.

STI Risk Considerations

For individuals who are not in mutually monogamous relationships with partners of known STI status, relying solely on the withdrawal method represents a significant health risk. The withdrawal method should only be considered as a contraceptive option when:

  • Both partners have been recently tested for STIs and are negative
  • The relationship is mutually monogamous
  • Both partners have discussed and agreed to this testing and relationship status

For those who cannot confirm all of these conditions, condom use remains essential for STI protection, regardless of what contraceptive method is used for pregnancy prevention. Condoms can be used in combination with withdrawal for added pregnancy protection while also providing STI protection.

How to Use the Withdrawal Method Correctly

To use the withdrawal method correctly, the penis must be completely withdrawn from the vagina well before ejaculation begins, with semen directed away from the vaginal area entirely. This requires experience recognizing pre-ejaculatory sensations, excellent self-control during arousal, clear communication between partners, and a backup plan if withdrawal is not successfully completed.

While the withdrawal method is inherently less reliable than many other contraceptive methods, using it correctly can improve its effectiveness from the typical-use rate of 80% to the perfect-use rate of approximately 96%. Understanding proper technique is important for those who choose to use this method, either as their primary contraception or as a backup method.

Step-by-Step Guidance

  1. Prior discussion and agreement: Both partners should explicitly discuss and agree to use the withdrawal method before sexual activity begins. The partner performing withdrawal must be genuinely committed to withdrawing in time every single time.
  2. Know your body: The person withdrawing must be familiar with their own pre-ejaculatory sensations. This awareness typically develops over time and may require conscious attention during solo masturbation to recognize the signs of approaching ejaculation.
  3. Timing the withdrawal: Withdrawal must occur well before the sensation of imminent ejaculation. Waiting until the "point of no return" is too late - by then, ejaculation cannot be stopped.
  4. Complete withdrawal: The penis must be completely removed from the vagina before any ejaculation begins. Partial withdrawal or withdrawal during ejaculation is insufficient.
  5. Direct semen away: After withdrawal, semen should be directed away from the vaginal area entirely. Ejaculation near the vaginal opening still poses pregnancy risk, as sperm can swim into the vagina.
  6. Post-ejaculation precautions: If having intercourse again, the person should urinate first to help flush any remaining sperm from the urethra, potentially reducing sperm in pre-ejaculate.

When Withdrawal Is More Likely to Succeed

Certain circumstances improve the likelihood of successful withdrawal. Experienced couples who have used the method over time typically achieve better results than those newly attempting it. Situations where arousal is more controlled (rather than extremely high) allow for better timing. Avoiding alcohol and other substances that impair judgment also improves success rates. Finally, combining withdrawal with other methods, such as using it only during less fertile times of the menstrual cycle, can provide additional protection.

🚨 Critical reminder

Even with perfect technique, the withdrawal method has a 4% failure rate due to factors like sperm in pre-ejaculate. This is substantially less effective than IUDs (0.1-0.8%), implants (0.1%), or even correctly used condoms (2%). Those seeking reliable pregnancy prevention should strongly consider these more effective alternatives.

What Should I Do If the Withdrawal Method Fails?

If withdrawal fails (ejaculation inside the vagina or near the vaginal opening), emergency contraception should be considered promptly. The copper IUD is the most effective option (99% effective up to 5 days after). Emergency contraceptive pills are also available and work best within 72 hours. Do not douche, as this can push sperm further into the reproductive tract.

Despite best intentions and technique, withdrawal sometimes fails. Ejaculation may occur before complete withdrawal, or semen may contact the vaginal area. When this happens, remaining calm while taking prompt action is important. Several emergency contraception options exist, each with different effectiveness windows and mechanisms.

Emergency Contraception Options

Copper IUD (ParaGard): The copper IUD is the most effective form of emergency contraception, preventing over 99% of pregnancies when inserted within 5 days (120 hours) of unprotected intercourse. It works by creating an environment toxic to sperm and can also prevent implantation of a fertilized egg. An additional benefit is that once inserted, it provides highly effective ongoing contraception for up to 10-12 years.

Ulipristal acetate (ella): This prescription emergency contraceptive pill is effective up to 5 days (120 hours) after unprotected intercourse, with no decrease in effectiveness over this period. It works primarily by delaying or preventing ovulation. Studies show it prevents about 85% of expected pregnancies.

Levonorgestrel (Plan B One-Step and generics): Available over the counter without age restrictions, this emergency contraceptive pill is most effective when taken within 72 hours (3 days) of unprotected intercourse, though it can be used up to 5 days after. Effectiveness decreases over time: approximately 89% effective within 72 hours, declining significantly thereafter. It may be less effective in women weighing over 165 pounds (75 kg).

What NOT to Do

Several common responses to withdrawal failure are ineffective or potentially harmful:

  • Do not douche: Douching does not prevent pregnancy and can actually push sperm further into the reproductive tract while disrupting vaginal flora.
  • Do not wait to see if pregnancy occurs: Emergency contraception is time-sensitive and becomes less effective with delay.
  • Do not panic: While prompt action is important, single exposures to unprotected intercourse do not always result in pregnancy. Emergency contraception significantly reduces risk.
Accessing emergency contraception:

Levonorgestrel emergency contraception is available at most pharmacies without a prescription. Ulipristal requires a prescription. Copper IUD insertion requires a healthcare appointment but should be prioritized given its superior effectiveness. Many clinics offer same-day emergency contraception services. Learn more about emergency contraception →

What Are the Advantages of the Withdrawal Method?

The withdrawal method offers several advantages: it is completely free, always available without planning or supplies, has no hormonal side effects, is fully reversible, and requires no medical appointment or prescription. For some couples, it may also feel more natural or intimate than barrier methods. However, these benefits must be weighed against its significant limitations.

While the withdrawal method is less effective than most other contraceptive options, understanding its genuine advantages helps explain why it remains used by millions of couples worldwide. For some individuals and couples, these advantages may make withdrawal an appropriate choice, either as a primary method (accepting the higher pregnancy risk) or as a supplementary method used alongside more reliable contraception.

Key Advantages

No cost: The withdrawal method requires no supplies, prescriptions, medical devices, or healthcare visits, making it completely free to use. For individuals facing financial barriers to healthcare or contraceptive access, this can be a significant consideration.

Always available: Unlike condoms, which must be purchased and carried, or hormonal methods, which require consistent use or medical insertion, withdrawal is always available as an option. This makes it useful as a backup method when other contraception is unavailable.

No hormonal effects: Many people experience side effects from hormonal contraceptives, including mood changes, weight fluctuation, decreased libido, or other symptoms. Withdrawal involves no hormones and thus produces no hormonal side effects.

No physical barriers: Some couples find that barrier methods like condoms reduce sensation or interrupt intimacy. While this is subjective and many couples use condoms without complaint, withdrawal eliminates this concern for those who have it.

Immediate reversibility: Fertility returns immediately after stopping withdrawal use, unlike hormonal methods where fertility may take time to return. This makes withdrawal suitable for couples who may want to become pregnant soon.

Partner involvement: Withdrawal requires active participation from the partner with a penis, which some couples view positively as shared responsibility for contraception. This contrasts with methods that place contraceptive burden primarily on one partner.

What Are the Disadvantages of the Withdrawal Method?

The withdrawal method has significant disadvantages: a 20% typical-use failure rate, no STI protection, reliance on self-control during arousal, potential for pre-ejaculate containing sperm, interrupted sexual experience for some couples, and placement of contraceptive responsibility primarily on one partner. These drawbacks make it one of the least recommended contraceptive methods.

The disadvantages of the withdrawal method are substantial and should be carefully considered by anyone thinking about using this method. For most couples wanting to reliably prevent pregnancy, these disadvantages outweigh the advantages discussed in the previous section.

Key Disadvantages

High failure rate: The 20% typical-use failure rate means approximately 1 in 5 couples will experience pregnancy within one year. This is among the highest failure rates of any contraceptive method, exceeded only by spermicide alone and various fertility awareness methods when used imperfectly.

No STI protection: The withdrawal method provides absolutely no protection against sexually transmitted infections. For anyone not in a confirmed mutually monogamous relationship with a partner of known STI status, this is a critical limitation.

Requires consistent self-control: Successful withdrawal requires maintaining conscious control during intense sexual arousal - a challenging task that becomes more difficult with factors like inexperience, alcohol use, or particularly high arousal.

Pre-ejaculate risk: Even with perfect withdrawal, sperm in pre-ejaculatory fluid can cause pregnancy. This inherent limitation cannot be overcome through better technique.

Interrupts sexual experience: While some couples adapt to withdrawal without concern, others find that the need to withdraw at the moment of highest arousal interrupts the sexual experience for one or both partners.

Anxiety and trust issues: Relying on withdrawal can create anxiety about whether it will be performed correctly, and requires a high level of trust between partners. This psychological burden can negatively affect sexual satisfaction and relationship dynamics.

Not suitable for all situations: Withdrawal may be inappropriate in casual encounters, new relationships, situations involving alcohol or drugs, or when one partner has difficulty predicting ejaculation.

What Are Better Alternatives to the Withdrawal Method?

More effective contraceptive alternatives include long-acting reversible contraceptives (IUDs and implants with 99%+ effectiveness), hormonal methods (pills, patches, rings with 91-99% effectiveness), barrier methods (condoms with 85-98% effectiveness plus STI protection), and permanent sterilization. Most methods are significantly more reliable than withdrawal's 80% typical-use effectiveness.

For couples seeking more reliable pregnancy prevention than the withdrawal method provides, numerous alternatives exist with varying characteristics, effectiveness rates, and considerations. Understanding these options allows informed decision-making based on individual needs, preferences, and circumstances.

Long-Acting Reversible Contraceptives (LARCs)

LARCs represent the most effective reversible contraceptive methods available, with failure rates below 1% for both perfect and typical use (since they don't depend on user behavior once inserted).

  • Hormonal IUDs (Mirena, Kyleena, Liletta, Skyla): Small T-shaped devices inserted into the uterus that release progestin locally. Effective for 3-8 years depending on type. Over 99% effective.
  • Copper IUD (Paragard): Hormone-free IUD effective for up to 10-12 years. The copper creates an environment hostile to sperm. Over 99% effective.
  • Implant (Nexplanon): A small rod inserted under the arm skin that releases progestin. Effective for up to 3 years. Over 99% effective.

Hormonal Methods

Hormonal methods prevent ovulation and/or create conditions unfavorable for pregnancy. Effectiveness depends on consistent use.

  • Combined oral contraceptives ("the pill"): 91-99% effective with proper use.
  • Progestin-only pills ("mini-pill"): 91-99% effective; suitable for those who cannot use estrogen.
  • Contraceptive patch: 91-99% effective; worn on skin, changed weekly.
  • Vaginal ring (NuvaRing): 91-99% effective; inserted monthly.
  • Injectable (Depo-Provera): 94-99% effective; injection every 3 months.

Barrier Methods

Barrier methods physically prevent sperm from reaching the egg and provide varying levels of STI protection.

  • Male condoms: 85-98% effective; the only method also protecting against most STIs.
  • Female condoms: 79-95% effective; inserted into vagina before intercourse.
  • Diaphragm with spermicide: 83-94% effective; reusable barrier covering the cervix.
Finding the right method:

Contraceptive choice is highly personal and depends on factors including effectiveness needs, side effect tolerance, STI concerns, future fertility plans, and personal preferences. Healthcare providers can help identify the best option for individual circumstances. Explore all contraceptive options →

Frequently Asked Questions About the Withdrawal Method

Medical References and Sources

This article is based on current medical research and international guidelines. All claims are supported by scientific evidence from peer-reviewed sources.

  1. World Health Organization (2023). "Family planning/contraception methods fact sheet." WHO Fact Sheet Comprehensive global data on contraceptive effectiveness.
  2. Trussell J, Aiken ARA, Micks E, Guthrie KA (2023). "Contraceptive efficacy." In: Hatcher RA et al., eds. Contraceptive Technology. 22nd ed. Standard reference for contraceptive failure rates. Evidence level: 1A
  3. Killick SR, Leary C, Trussell J, Guthrie KA (2011). "Sperm content of pre-ejaculatory fluid." Human Fertility. 14(1):48-52. DOI: 10.3109/14647273.2010.520798 Key study on sperm presence in pre-ejaculatory fluid.
  4. Faculty of Sexual and Reproductive Healthcare (FSRH) (2023). "UK Medical Eligibility Criteria for Contraceptive Use." FSRH Guidelines Clinical guidelines for contraceptive prescribing.
  5. American College of Obstetricians and Gynecologists (ACOG) (2023). "Practice Bulletin: Contraception." US clinical practice guidelines for contraceptive care.
  6. Curtis KM, et al. (2016). "U.S. Medical Eligibility Criteria for Contraceptive Use, 2016." MMWR Recomm Rep. 65(3):1-103. CDC MMWR CDC recommendations for contraceptive use.
  7. Pudney J, Oneta M, Mayer K, Seage G, Anderson D (1992). "Pre-ejaculatory fluid as potential vector for sexual transmission of HIV-1." Lancet. 340(8833):1470. Early research on pre-ejaculate and STI transmission.

Evidence grading: This article uses the GRADE framework (Grading of Recommendations Assessment, Development and Evaluation) for evidence-based medicine. Effectiveness data is primarily drawn from systematic analyses of large population studies and clinical trials.

⚕️

iMedic Medical Editorial Team

Specialists in reproductive health and sexual medicine

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