Noviform (Bibrokatol) Eye Ointment
Antiseptic ophthalmic ointment for minor eye infections and eyelid inflammation
Noviform is an over-the-counter eye ointment containing the active ingredient bibrokatol, which has both antibacterial (bacteriostatic) and anti-inflammatory properties. It is used to treat temporary eye complaints including mild inflammation of the eyelids (blepharitis), conjunctivitis, styes (hordeolum), and other minor external eye conditions. Noviform is applied topically to the inner eyelid and is generally well tolerated with very few reported side effects.
Quick Facts
Key Takeaways
- Noviform contains bibrokatol, an antiseptic with both antibacterial and anti-inflammatory effects on the external eye.
- It is available over the counter (OTC) and is used for mild blepharitis, conjunctivitis, styes, and other minor eye complaints.
- Apply a 0.5–1 cm strip of ointment to the inner lower eyelid 1–2 times daily, preferably at bedtime due to temporary blurred vision.
- No drug interactions have been reported; it is considered safe during pregnancy, though breastfeeding mothers should consult a healthcare provider.
- Side effects are very rare; opened tubes should be used within one month and stored out of reach of children.
What Is Noviform and What Is It Used For?
Noviform is a topical ophthalmic ointment that contains bibrokatol as its active ingredient. Bibrokatol is a bismuth-containing antiseptic compound that has been used in ophthalmology for decades to manage superficial eye infections and inflammatory conditions affecting the external structures of the eye. The medication is classified as an antiseptic ophthalmic agent and is available without a prescription in many countries.
The primary mechanism of action of bibrokatol involves two complementary effects. First, it exerts a bacteriostatic effect, meaning it inhibits the growth and reproduction of bacteria on the surface of the eye and eyelids without necessarily killing them outright. Second, it provides an anti-inflammatory effect that helps reduce swelling, redness, and discomfort associated with minor ocular surface conditions. This dual action makes Noviform particularly useful for conditions where both infection and inflammation are present simultaneously.
Noviform is indicated for the treatment of temporary eye complaints, including mild inflammation of the eyelids (blepharitis), inflammation of the conjunctiva (the thin membrane that covers the inside of the eyelids and the white part of the eye), styes (hordeolum, which are small, painful lumps that develop on the eyelid), and other minor external eye conditions. The conjunctiva is a thin, transparent tissue that lines the inner surface of the eyelids and covers the sclera (the white part of the eye). When this tissue becomes inflamed, it can cause redness, discharge, and a gritty sensation.
Blepharitis is one of the most common conditions treated with Noviform. This chronic condition involves inflammation of the eyelid margins and is often caused by bacterial colonization, particularly by Staphylococcus species. Symptoms include crusty eyelids upon waking, a burning or stinging sensation, and eyelids that appear red and swollen. According to the American Academy of Ophthalmology (AAO), blepharitis affects a substantial proportion of ophthalmology patients, and topical antiseptic agents like bibrokatol play a role in its management alongside eyelid hygiene measures.
It is important to consult a healthcare provider if symptoms do not improve within a few days of treatment. Persistent or worsening eye symptoms may indicate a more serious condition that requires prescription medication or specialist evaluation.
What Should You Know Before Using Noviform?
Contraindications
Noviform should not be used by individuals who have a known allergy (hypersensitivity) to bibrokatol or to any of the other ingredients contained in the formulation. The excipients include wool fat (lanolin), cetostearyl alcohol, white petrolatum (white vaseline), and liquid paraffin. Patients with known sensitivity to lanolin-containing products should exercise particular caution, as lanolin is a recognized contact allergen that can trigger localized skin reactions, including contact dermatitis.
If you have previously experienced an allergic reaction to any bismuth-containing compound, you should inform your healthcare provider before using Noviform. Although cross-reactivity is uncommon, it is prudent to discuss your medical history with a pharmacist or doctor to determine whether Noviform is appropriate for your situation.
Warnings and Precautions
Noviform eye ointment can temporarily form a thin film over the surface of the eye after application, which may cause blurred or dim vision. This effect is normal and expected with any eye ointment formulation, as the oily base takes time to disperse across the ocular surface. Because of this temporary visual impairment, you should not drive a car, operate heavy machinery, or perform tasks that require sharp visual acuity until your vision has fully cleared.
The ointment contains cetostearyl alcohol and wool fat (lanolin), both of which are known to occasionally cause localized skin irritation, particularly in the form of contact dermatitis or eczema. If you develop increased redness, itching, or swelling after applying the ointment, discontinue use and seek medical advice. These reactions are uncommon but should be taken seriously if they occur.
Noviform may stain clothing and bed linen due to its yellow coloration. Take precautions when applying the ointment, particularly at bedtime, to avoid contact with fabrics.
If you wear contact lenses, you should remove them before applying Noviform and wait at least 15–30 minutes before reinserting them. The oily base of the ointment can coat the lens surface and impair vision further, and some of the excipients may interact with contact lens materials.
Pregnancy and Breastfeeding
There are no known risks associated with using Noviform during pregnancy. Bibrokatol is applied topically to the eye surface and has minimal systemic absorption, which means it is unlikely to reach the developing fetus in significant quantities. Nevertheless, as with all medications during pregnancy, it is advisable to use Noviform only when clearly needed and to consult with a healthcare provider if you have any concerns.
It is currently unknown whether bibrokatol passes into breast milk. Given the topical nature of the application and the low systemic absorption, the risk to a nursing infant is considered to be very low. However, as a precaution, breastfeeding mothers should consult a healthcare provider or pharmacist before using this medicine. If use is deemed necessary, the mother should be advised to apply the ointment immediately after breastfeeding to maximize the interval before the next feed.
Driving and Operating Machinery
Because Noviform eye ointment can temporarily impair vision by forming a film over the eye surface, patients should not drive or operate machinery until clear vision has been restored. This effect typically resolves within 15–30 minutes after application, but the duration can vary between individuals. Applying the ointment at bedtime minimizes the impact on daily activities that require clear vision.
How Does Noviform Interact with Other Drugs?
One of the notable advantages of Noviform is its excellent drug interaction profile. No cases of Noviform affecting or being affected by other medications have been documented in the medical literature or in post-marketing surveillance data. This favorable safety profile is primarily attributable to the drug's local mechanism of action and minimal systemic absorption when applied topically to the eye.
Because bibrokatol exerts its antibacterial and anti-inflammatory effects directly on the surface of the eye, very little of the active substance enters the systemic circulation. This means that the drug does not reach plasma concentrations high enough to interact with other medications that may be circulating in the bloodstream. This makes Noviform a particularly practical choice for patients who are taking multiple medications (polypharmacy), as there is no need to adjust the timing or dosage of other drugs.
Concurrent Use with Other Eye Medications
While no formal drug interactions have been identified, patients who use other topical eye medications (such as eye drops for glaucoma, dry eyes, or allergies) should allow a minimum interval of 5–10 minutes between applications. Eye ointments like Noviform should generally be applied last in any sequence of ophthalmic medications, as the oily base can form a barrier that may reduce the absorption of subsequently applied eye drops.
According to general ophthalmic prescribing principles endorsed by the European Medicines Agency (EMA) and the American Academy of Ophthalmology (AAO), the recommended order of application when using multiple eye medications is: eye drops first, then eye gels, and finally eye ointments. This ensures optimal absorption of each medication.
| Medication Category | Interaction Risk | Clinical Recommendation |
|---|---|---|
| Oral medications (all types) | None reported | No dose adjustment needed |
| Other eye drops (e.g., glaucoma, allergy) | None (pharmacokinetic) | Apply drops first, wait 5–10 min, then apply Noviform |
| Other eye ointments | Potential reduced absorption | Separate applications by at least 10 minutes |
| Contact lens solutions | Physical incompatibility | Remove lenses before application; wait 15–30 min before reinsertion |
| Herbal supplements | None reported | No precautions needed |
Despite the absence of documented interactions, patients should always inform their healthcare provider or pharmacist about all medications they are currently using, including prescription drugs, over-the-counter products, and herbal supplements. This comprehensive medication review helps ensure that all potential risks are considered, even in cases where specific interaction data may be limited.
What Is the Correct Dosage of Noviform?
The recommended dosage of Noviform is standardized and straightforward, which reflects its over-the-counter status and favorable safety profile. The product is supplied as a 5-gram tube of yellow ointment containing bibrokatol at a concentration of 50 mg per gram. Always use this medicine exactly as described in the product information leaflet, or as directed by a healthcare provider, pharmacist, or nurse.
Adults
Standard Adult Dosage
Apply a thin strip of ointment (approximately 0.5–1 cm in length) to the inside of one or both lower eyelids, 1–2 times daily. For optimal results, one application should be performed at bedtime, as the ointment may temporarily cause blurred vision. If a second daily application is needed, it should be timed when clear vision is not immediately required.
Children
Pediatric Dosage
Before treating children with Noviform, parents or caregivers should consult a doctor or nurse for professional advice. While bibrokatol is not contraindicated in children, a healthcare provider should evaluate the child's condition to confirm that it is appropriate for self-treatment with an over-the-counter product. Children may present with eye conditions that appear minor but require prescription therapy, and a professional assessment helps ensure proper diagnosis.
Elderly
Dosage in Older Adults
No dose adjustment is required for older adults. The standard adult dosage applies. Elderly patients who have difficulty applying eye ointment due to arthritis or tremor may benefit from having a caregiver assist with the application process. Proper hand hygiene before application is essential regardless of who applies the ointment.
How to Apply Noviform Eye Ointment
Proper application technique is important to maximize the therapeutic benefit of Noviform while minimizing the risk of contamination. Follow these steps carefully:
- Wash your hands thoroughly with soap and water before handling the tube.
- Separate the eyelids by gently pulling down the lower eyelid with a clean finger to create a small pocket.
- Apply the ointment by squeezing a thin strip (0.5–1 cm) from the tube tip into the pocket formed by the lower eyelid. Avoid touching the tube tip directly to the eye, eyelid, or any other surface to prevent bacterial contamination.
- Close and massage your eyes gently and massage the eyelids lightly in the direction toward the nose to distribute the ointment evenly over the eye surface.
- Replace the cap on the tube immediately after use to maintain sterility.
Because the ointment may temporarily blur vision, applying Noviform at bedtime is the most practical approach. This allows the medication to work throughout the night while the eyes are closed, and vision will typically be clear by morning.
Missed Dose
If you forget to apply Noviform at the scheduled time, apply it as soon as you remember. However, do not apply a double dose to make up for a missed application. Simply continue with your regular dosing schedule. If you are unsure about what to do, consult a pharmacist or healthcare provider for guidance.
Overdose
In the event that an excessive amount of Noviform is applied to the eye, or if the product is accidentally ingested (for example, by a child), contact a healthcare provider, hospital emergency department, or poison control center for an assessment of the risk and appropriate advice. While serious toxicity from topical ocular application of bibrokatol has not been reported, accidental ingestion should be evaluated by a medical professional as a precautionary measure.
| Patient Group | Dosage | Frequency | Notes |
|---|---|---|---|
| Adults | 0.5–1 cm strip | 1–2 times daily | Preferably at bedtime |
| Children | 0.5–1 cm strip | 1–2 times daily | Consult a healthcare provider first |
| Elderly | 0.5–1 cm strip | 1–2 times daily | No dose adjustment required |
| Pregnant women | 0.5–1 cm strip | 1–2 times daily | No known risks; use as directed |
What Are the Side Effects of Noviform?
Like all medicines, Noviform can cause side effects, although not everybody gets them. Overall, bibrokatol eye ointment has an excellent tolerability profile, and the vast majority of users experience no adverse effects during treatment. The side effects that have been reported are classified according to their frequency, as defined by international pharmacovigilance standards set by the Council for International Organizations of Medical Sciences (CIOMS) and adopted by the European Medicines Agency (EMA).
The frequency classification system used below follows the standard categories: very common (affects more than 1 in 10 users), common (affects 1 in 10 to 1 in 100 users), uncommon (affects 1 in 100 to 1 in 1,000 users), rare (affects 1 in 1,000 to 1 in 10,000 users), and very rare (affects fewer than 1 in 10,000 users).
Very Rare
Affects fewer than 1 in 10,000 users
- Swelling around the eyes (periorbital edema)
- Redness around the eyes (periorbital erythema)
Allergic Reactions (Frequency Not Determined)
May occur in susceptible individuals
- Allergic reaction to bibrokatol (contact hypersensitivity)
- Allergic reaction to cetostearyl alcohol (contact dermatitis)
- Allergic reaction to wool fat/lanolin (contact eczema)
- Localized skin irritation at the application site
Understanding the Side Effects
The very rare occurrence of swelling and redness around the eyes (periorbital edema and erythema) typically resolves upon discontinuation of the ointment. These reactions are thought to be related to individual sensitivity to the active ingredient or one of the excipients rather than a direct pharmacological effect of the drug. If you notice any swelling, persistent redness, or increased discomfort after applying Noviform, stop using the product and consult a healthcare provider.
Allergic reactions to the excipients in Noviform—particularly wool fat (lanolin) and cetostearyl alcohol—are a known phenomenon that is not unique to this product. Lanolin allergy affects an estimated 1.7–6.9% of patients with dermatological conditions, according to studies published in the British Journal of Dermatology and Contact Dermatitis. Patients who have a history of contact dermatitis or eczema may be at slightly higher risk and should be aware of this possibility.
It is worth noting that the temporary blurred vision experienced after applying any eye ointment (not just Noviform) is a normal physical effect of the ointment base covering the corneal surface and is not classified as a side effect. This temporary visual disturbance typically clears within 15–30 minutes as the ointment disperses and absorbs.
Although extremely rare, if you experience signs of a severe allergic reaction such as significant facial swelling, difficulty breathing, or widespread hives after using Noviform, discontinue use immediately and seek emergency medical care. These symptoms may indicate anaphylaxis, which requires urgent treatment.
Reporting Side Effects
It is important to report any suspected side effects after a medicine has been authorized for sale. Reporting helps regulatory authorities continuously monitor the benefit-risk balance of medicines. Healthcare professionals and patients are encouraged to report suspected adverse reactions to their national pharmacovigilance authority. In the United Kingdom, reports can be made through the Yellow Card Scheme. In the United States, reports can be submitted to the FDA MedWatch program. In the European Union, reports can be submitted through the national competent authority of each member state.
How Should You Store Noviform?
Proper storage of Noviform is essential to maintain the efficacy and sterility of the eye ointment throughout its usable life. As an ophthalmic product, it is particularly important to protect the ointment from contamination, as the eye is a sensitive organ that is susceptible to infection from contaminated products.
Store Noviform out of the sight and reach of children at all times. The tube should be kept in its original packaging to protect it from light and to ensure that the product information is readily available when needed. There are no specific temperature storage requirements listed beyond standard room temperature conditions, but avoid exposing the tube to extreme heat or direct sunlight, as this may alter the physical properties of the ointment base.
After Opening
Once the tube has been opened, the ointment should be used within one month. This one-month post-opening shelf life is standard for ophthalmic ointments and is based on the risk of microbial contamination that increases with repeated opening and use. After one month, discard the tube even if there is product remaining. Write the date of first opening on the tube or its box to help track this period.
Expiration Date
Do not use Noviform after the expiration date printed on the packaging (indicated by "EXP"). The expiration date refers to the last day of the month indicated. Using expired eye products is not recommended, as the chemical stability and sterility of the formulation cannot be guaranteed beyond the stated date.
Disposal
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines that are no longer needed. These measures help protect the environment by preventing pharmaceutical compounds from entering water systems and soil. Many pharmacies offer take-back programs for unused or expired medications.
What Does Noviform Contain?
Understanding the composition of Noviform is important for identifying potential allergens and understanding how the product works. The formulation consists of one active ingredient and four excipients (inactive ingredients), each serving a specific function in the ointment.
Active Ingredient
Bibrokatol — Each gram of Noviform eye ointment contains 50 mg of bibrokatol (5% w/w). Bibrokatol (also known as bibrocathol) is a bismuth-containing organic compound with the molecular formula C6H3Bi(OH)2Br2O. It has been used as a topical antiseptic in ophthalmology since the early 20th century. The compound exerts its therapeutic effects through bacteriostatic (bacterial growth-inhibiting) and anti-inflammatory actions on the external eye structures.
Inactive Ingredients (Excipients)
- Wool fat (lanolin): A natural emollient derived from sheep's wool that helps the ointment spread smoothly and adhere to the ocular surface. It provides a protective barrier and helps retain moisture. Note that lanolin is a recognized contact allergen in some individuals.
- Cetostearyl alcohol: A mixture of cetyl and stearyl alcohols that acts as an emulsifier and thickening agent, providing the ointment with its semi-solid consistency. This compound may cause localized skin irritation (contact dermatitis) in sensitive individuals.
- White petrolatum (white vaseline): A highly refined mineral oil-based substance that serves as the primary ointment base. It provides an occlusive barrier that helps maintain the contact of bibrokatol with the eye surface for a prolonged period.
- Liquid paraffin (mineral oil): A light mineral oil that improves the consistency and spreadability of the ointment, making it easier to apply and distribute across the eye surface.
Appearance and Packaging
Noviform eye ointment is a yellow-colored ointment supplied in an aluminum tube containing 5 grams of product. The tube is fitted with a fine-pointed nozzle designed for precise application to the eyelid. The yellow color of the ointment is characteristic of bibrokatol and is normal; however, be aware that this coloration can transfer to clothing, bed linen, and other fabrics.
Marketing Authorization Holder
Cooper Consumer Health B.V., Verrijn Stuartweg 60, 1112AX Diemen, Netherlands. Cooper Consumer Health is a consumer healthcare company specializing in over-the-counter pharmaceutical products for self-care across multiple therapeutic areas.
Frequently Asked Questions About Noviform
Noviform contains bibrokatol, an antiseptic agent that inhibits bacterial growth (bacteriostatic effect), whereas antibiotic eye drops such as chloramphenicol or fusidic acid contain antibiotics that directly kill bacteria (bactericidal effect). Noviform is available over the counter and is suitable for mild, self-limiting eye conditions like minor blepharitis, mild conjunctivitis, and styes. Antibiotic eye drops are typically prescription medications reserved for more significant bacterial infections. If your symptoms are severe, persistent, or accompanied by purulent (pus-like) discharge, you should see a healthcare provider who may prescribe antibiotic therapy.
You should remove contact lenses before applying Noviform eye ointment and wait at least 15–30 minutes before reinserting them. The oily base of the ointment can coat the lens surface, impair vision, and potentially interact with contact lens materials. It is generally advisable to avoid wearing contact lenses entirely while treating an active eye infection, as lenses can harbor bacteria and slow the healing process. Consult your eye care professional for guidance specific to your situation.
Many users notice improvement in their symptoms within 1–3 days of starting treatment with Noviform. The anti-inflammatory effect may provide relief from redness and swelling relatively quickly, while the antibacterial effect works over several days to reduce bacterial colonization. However, if you do not notice any improvement within a few days, you should consult a healthcare provider, as your condition may require a different treatment approach. Do not continue self-treatment for prolonged periods without professional evaluation.
Noviform is not specifically contraindicated in children; however, the manufacturer recommends that a healthcare provider (doctor or nurse) be consulted before treating children with this product. Eye conditions in children may sometimes appear minor but require professional assessment to rule out more serious causes. A healthcare provider can confirm the diagnosis and determine whether Noviform is the most appropriate treatment for the child's specific condition.
Noviform can be used for mild conjunctivitis (inflammation of the conjunctiva), which is one of its indicated uses. However, it is important to understand that conjunctivitis can be caused by bacteria, viruses, or allergies, and each type requires different treatment. Noviform is most appropriate for mild bacterial conjunctivitis. Viral conjunctivitis will not respond to antiseptic treatment and usually resolves on its own. Allergic conjunctivitis requires antihistamine eye drops. If you are unsure about the cause of your conjunctivitis, or if symptoms are severe (heavy discharge, significant pain, or vision changes), consult a healthcare provider for proper diagnosis.
Temporary blurred vision after applying Noviform is caused by the oily ointment base (composed of white petrolatum, liquid paraffin, and wool fat) spreading across the corneal surface and forming a thin film. This film temporarily disrupts the smooth optical surface of the tear film, causing light to scatter rather than focus properly on the retina. This effect is common to all eye ointment formulations, not just Noviform, and typically resolves within 15–30 minutes as the ointment disperses and is absorbed. It is not a side effect of the active ingredient bibrokatol.
References
This article is based on evidence from the following peer-reviewed sources, international guidelines, and regulatory documents:
- European Medicines Agency (EMA). Guideline on the Pharmaceutical Quality of Ophthalmic Preparations. EMA/CHMP/QWP/558185/2021. European Medicines Agency, 2022.
- American Academy of Ophthalmology (AAO). Preferred Practice Pattern: Blepharitis. American Academy of Ophthalmology, 2024.
- World Health Organization (WHO). WHO Model List of Essential Medicines, 23rd edition. World Health Organization, 2023.
- Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database of Systematic Reviews. 2012;(5):CD005556. doi:10.1002/14651858.CD005556.pub2
- National Institute for Health and Care Excellence (NICE). Clinical Knowledge Summaries: Blepharitis. NICE, 2023.
- Bowling B. Kanski's Clinical Ophthalmology: A Systematic Approach, 9th edition. Elsevier, 2023.
- Warshaw EM, Maibach HI, et al. Contact dermatitis of the eyelids: a review. Dermatitis. 2022;33(2):106-117.
- Cooper Consumer Health B.V. Noviform (bibrokatol) Summary of Product Characteristics. Revised September 2025.
- British National Formulary (BNF). Eye Infections: Antibacterial Preparations. NICE/BNF, 2024.
- Council for International Organizations of Medical Sciences (CIOMS). Guidelines for Preparing Core Clinical Safety Information on Drugs, 3rd edition. CIOMS/WHO, 2020.
Editorial Team
This article has been written and reviewed by the iMedic Medical Editorial Team, consisting of licensed physicians and pharmacologists with expertise in ophthalmology and clinical pharmacology.
iMedic Medical Editorial Team — Specialist physicians in ophthalmology and clinical pharmacology with extensive experience in evidence-based medical communication.
iMedic Medical Review Board — Independent panel of medical experts who review all content according to international guidelines from WHO, EMA, AAO, and NICE.
Conflict of Interest: The iMedic Medical Editorial Team and Review Board declare no conflicts of interest. iMedic receives no commercial funding, pharmaceutical sponsorship, or advertising revenue. All content is produced independently.
Evidence Framework: This article follows the GRADE (Grading of Recommendations Assessment, Development and Evaluation) evidence framework and adheres to international guidelines from the WHO, EMA, AAO, and NICE.