Naltrexone for Opioid use disorder
Quick answer: Naltrexone is used for Opioid use disorder as part of a opioid antagonist treatment regimen. Long-acting competitive opioid receptor antagonist blocking opioid effects and reducing alcohol craving The specific dosing for Opioid use disorder is determined by your prescriber based on individual factors.
Why is Naltrexone used for Opioid use disorder?
Naltrexone belongs to the Opioid antagonist class. Long-acting competitive opioid receptor antagonist blocking opioid effects and reducing alcohol craving This action makes it useful for treating or managing Opioid use disorder in patients for whom this approach is clinically appropriate.
It is one of several treatment options. Whether Naltrexone is the right choice for a specific patient depends on the type and severity of Opioid use disorder, response to previous treatments, individual risk factors, and clinical guidelines.
Typical dosing for Opioid use disorder
Common adult dosing range: 50 mg orally once daily; 380 mg IM monthly (extended-release). The actual dose for Opioid use disorder depends on:
- Severity of the condition
- Patient's age, weight, and organ function
- Other medications being taken
- Treatment response and tolerability
For complete dosing details, see the Naltrexone medicine page.
What to expect
Naltrexone treatment for Opioid use disorder typically involves:
- Onset of effect: varies by indication and dose — some effects are immediate, others take days to weeks
- Treatment duration: some courses are short-term, others are long-term or lifelong depending on Opioid use disorder
- Monitoring: follow-up visits to assess response and adjust dosing
- Side-effect awareness: learning what to expect and what warrants medical attention
Alternatives to consider
If Naltrexone is not appropriate or not tolerated, alternatives within the same class or different therapeutic classes may be considered. See all Opioid antagonist for related options.
When to talk to your doctor
Discuss with your prescriber if you experience:
- Inadequate symptom control on Naltrexone
- Side effects affecting daily life
- New medications or supplements that may interact
- Pregnancy planning or pregnancy
- Major changes in health status
Related information
Naltrexone full prescribing information · All Opioid antagonist alternatives
Frequently asked questions
How effective is Naltrexone for Opioid use disorder?
Effectiveness varies by individual response, dose, and severity. Naltrexone is one of several treatment options for Opioid use disorder, supported by clinical evidence within the opioid antagonist class. Discuss expected response with your prescriber.
How long do I need to take Naltrexone for Opioid use disorder?
Treatment duration depends on the nature of Opioid use disorder — some treatments are short-term, others long-term or lifelong. Never stop on your own; discontinuation requires clinical guidance to avoid relapse or rebound effects.
What are the main side effects of Naltrexone when used for Opioid use disorder?
Common and serious side effects are class-related and substance-specific. See the full medicine page for the complete profile. Report any unexpected effects to your prescriber.
Are there alternatives to Naltrexone for Opioid use disorder?
Yes. Multiple medicines and non-drug options exist for Opioid use disorder. Alternatives within the opioid antagonist class share mechanisms; other classes may offer different approaches. Discuss with your clinician.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.