Locobase LPL (Propylene Glycol + Lactic Acid)
Descaling and moisturizing cream for dry, thickened, and scaly skin
Locobase LPL is a topical cream containing propylene glycol and lactic acid that works as both an emollient and a keratolytic agent. It is primarily used to treat thickened, dry, and hardened skin, including conditions such as ichthyosis. The cream draws moisture into the outer layer of the skin while gently breaking down excess scales, restoring a softer and more hydrated skin surface. Locobase LPL is available over the counter and is suitable for use by both adults and children.
Quick Facts
Key Takeaways
- Locobase LPL combines propylene glycol (humectant) and lactic acid (keratolytic) to moisturize and descale thickened, dry skin.
- It is commonly used for ichthyosis and other conditions causing severely dry, hardened, or scaly skin.
- Apply 1–2 times daily, preferably immediately after bathing or showering for maximum absorption.
- Available without a prescription (OTC) and safe for use during pregnancy, though avoid applying to nipples while breastfeeding.
- Common side effects include mild skin irritation with warmth and stinging; serious side effects such as allergic reactions are rare.
What Is Locobase LPL and What Is It Used For?
Locobase LPL is a medicated topical cream designed specifically for the treatment of skin that has become abnormally thick, dry, and scaly. Its dual-action formula combines propylene glycol at a concentration of 200 mg/g with lactic acid at 45 mg/g. These two active ingredients work synergistically to address both the moisture deficit and the excessive buildup of dead skin cells that characterize conditions such as ichthyosis.
Propylene glycol functions as a potent humectant, a substance that attracts and retains water within the stratum corneum (the outermost layer of the skin). By increasing the water content of this layer, propylene glycol helps to restore the skin's natural pliability and softness. Unlike simple occlusive moisturizers that merely form a barrier on the skin surface, propylene glycol actively draws moisture from the deeper dermal layers and the surrounding environment into the superficial skin, providing longer-lasting hydration.
Lactic acid belongs to the alpha-hydroxy acid (AHA) family and serves as a keratolytic agent in this formulation. It works by loosening the intercellular bonds (desmosomes) between corneocytes — the dead skin cells that make up the outermost layers of the epidermis. In conditions like ichthyosis, these cells accumulate excessively due to defective desquamation (natural shedding). By promoting gentle chemical exfoliation, lactic acid helps to thin the abnormally thickened stratum corneum, reduce visible scaling, and improve the overall texture and appearance of the skin.
Conditions Treated
Locobase LPL is indicated for the following conditions and clinical scenarios:
- Ichthyosis — A group of inherited skin disorders characterized by dry, scaly, thickened skin. Locobase LPL is recommended for ongoing management in patients who have received a prior diagnosis and initial treatment from a physician.
- Xerosis (severe dry skin) — Chronic dryness that does not respond adequately to regular moisturizers, particularly common in elderly patients and those living in dry or cold climates.
- Hyperkeratosis — Abnormal thickening of the outer layer of the skin, which can occur on areas such as the feet, elbows, and knees.
- Keratosis pilaris — Small, rough bumps caused by a buildup of keratin around hair follicles, often appearing on the upper arms and thighs.
- Psoriasis-related scaling — As an adjunctive descaling treatment to help remove thick plaques prior to the application of other topical therapies.
It is important to note that Locobase LPL is a symptomatic treatment — it manages and alleviates the signs and symptoms of dry, thickened skin but does not address the underlying genetic or pathological cause of these conditions. For ichthyosis in particular, initial diagnosis and treatment planning should be conducted by a dermatologist or other qualified healthcare professional. If new or unusual skin changes develop during self-treatment, medical consultation is advised.
What Should You Know Before Using Locobase LPL?
Contraindications
Locobase LPL should not be used if you have a known allergy (hypersensitivity) to any of its ingredients, including:
- Propylene glycol — The primary active humectant. Although relatively rare, propylene glycol allergy does occur and can manifest as contact dermatitis. Patch testing may be required to confirm this allergy.
- Lactic acid — The keratolytic active ingredient. True allergy to lactic acid is uncommon but can cause irritant or allergic contact reactions in sensitive individuals.
- Cetostearyl alcohol — An excipient (inactive ingredient) that can cause localized skin reactions, particularly contact eczema. Cetostearyl alcohol allergy is a well-recognized phenomenon in dermatology.
- Methylparaben (E218) — A preservative that can cause allergic reactions, sometimes with a delayed onset. Paraben sensitivity affects a small percentage of the population.
- Any other inactive ingredients listed in the composition section of this page.
Warnings and Precautions
Avoid applying Locobase LPL in the ear canal. Do not allow the cream to come into contact with the eyes, open wounds, or severely damaged skin (such as burns). If accidental contact occurs, rinse immediately with plenty of water.
When using Locobase LPL, the following precautions should be observed:
- Ear canals: Do not apply the cream inside the ears. Propylene glycol and lactic acid can cause irritation to the delicate skin lining of the ear canal and potentially affect the tympanic membrane.
- Eyes: Avoid getting the cream into or near the eyes. If accidental contact occurs, flush the eyes thoroughly with clean, lukewarm water for at least 15 minutes.
- Open wounds and damaged skin: Do not apply to broken skin, open sores, or areas with severe burns. Lactic acid can cause significant stinging and pain on compromised skin barriers, and propylene glycol may be absorbed systemically through damaged skin at higher rates than intended.
- Mucous membranes: Avoid application to mucous membranes (inside the mouth, nose, or genital area) as this can cause irritation.
- Medical follow-up: If symptoms do not improve or worsen within three weeks of regular use, discontinue self-treatment and consult a healthcare provider. Persistent symptoms may indicate an underlying condition that requires different management.
Pregnancy and Breastfeeding
Locobase LPL can be safely used during pregnancy. Topical application of propylene glycol and lactic acid at the concentrations used in this product does not pose known risks to the developing fetus, as systemic absorption through intact skin is minimal.
During breastfeeding, the cream should not be applied to the nipples or breast area where the infant may come into direct contact with the product. This precaution is to prevent the infant from unnecessarily ingesting propylene glycol and lactic acid. Application to other body areas during breastfeeding is considered safe.
As with all medications, it is advisable to consult your healthcare provider or pharmacist if you have any concerns about using Locobase LPL during pregnancy or while breastfeeding.
Driving and Operating Machinery
Locobase LPL does not affect your ability to drive or operate machinery. As a topical emollient and keratolytic, it acts locally on the skin and does not produce any systemic effects that could impair alertness, concentration, or motor function.
How Does Locobase LPL Interact with Other Medications?
Because Locobase LPL is applied topically and has minimal systemic absorption through intact skin, clinically meaningful drug interactions with oral or injectable medications are not expected. However, there are several practical considerations when using Locobase LPL alongside other topical treatments:
Topical Medication Considerations
| Medication Type | Consideration | Recommendation |
|---|---|---|
| Topical corticosteroids | Propylene glycol may enhance percutaneous absorption of corticosteroids | Apply Locobase LPL first, wait 15–30 minutes, then apply corticosteroid |
| Topical retinoids | Combined use may increase skin irritation due to additive keratolytic effects | Apply at different times of day (e.g., retinoid at night, Locobase LPL in the morning) |
| Other AHA/BHA products | Risk of excessive exfoliation and skin irritation with combined keratolytic agents | Avoid simultaneous use; alternate products on different days if needed |
| Topical antifungals | No significant interaction expected | Separate application times by at least 30 minutes |
| Calcineurin inhibitors (tacrolimus, pimecrolimus) | Propylene glycol may theoretically enhance absorption | Apply to different areas or separate application times by 1–2 hours |
As a general rule, when using multiple topical products, apply them at different times or allow at least 15–30 minutes between applications. This ensures that each product has adequate time to be absorbed and exert its intended effect without interference. If you are unsure about the compatibility of Locobase LPL with your current topical medications, consult your dermatologist or pharmacist.
Inform your healthcare provider about all medications you are currently using, including prescription drugs, over-the-counter products, and herbal supplements, even though systemic interactions with Locobase LPL are not expected. This is part of standard good practice for comprehensive pharmaceutical care.
What Is the Correct Dosage of Locobase LPL?
Locobase LPL should be used exactly as described in the patient information leaflet or as directed by your healthcare provider. The standard recommended dosage is the same for adults and children, though application areas and quantities will vary depending on the extent of skin involvement.
Adults
Standard Adult Dosage
Frequency: Apply 1–2 times daily
Application: Apply a thin, even layer to affected areas of thickened, dry, or hardened skin
Timing: Ideally apply immediately after bathing or showering when the skin is still slightly damp. This maximizes the humectant effect of propylene glycol, as it can draw residual moisture into the stratum corneum.
Duration: Continue use for as long as symptoms persist. For chronic conditions like ichthyosis, long-term regular use is typically necessary.
Children
Pediatric Dosage
Frequency: Apply 1–2 times daily, same as adults
Application: Apply a thin layer to affected skin areas. In younger children, a parent or caregiver should apply the cream.
Special note: Children may experience more noticeable stinging or warmth upon application, particularly if the skin barrier is significantly compromised. If irritation is excessive, reduce application frequency to once daily or consult a pediatric dermatologist.
Elderly
Elderly Dosage
Frequency: Apply 1–2 times daily, same as standard adult dosage
Consideration: Elderly patients frequently experience xerosis (age-related dry skin) and may benefit from more liberal and widespread application. The skin of elderly patients tends to be thinner, so they may be slightly more susceptible to irritation from lactic acid. If persistent irritation occurs, frequency can be reduced.
Application Tips
- After bathing: For optimal results, apply immediately after a bath or shower while the skin is still slightly damp. Pat the skin gently with a towel (do not rub dry) before applying.
- Pump dispenser: If using the 490 g pump container, tap the container against a firm surface a few times before use to ensure the cream reaches the pump mechanism for best dispensing performance.
- Thin layer: Apply a thin, even layer rather than a thick glob. The cream should be gently massaged into the skin until it is largely absorbed.
- Hands: Wash your hands after application unless you are treating the skin on your hands.
- Clothing: Allow the cream to absorb for a few minutes before putting on tight-fitting clothing to avoid transfer.
Missed Dose
If you forget to apply Locobase LPL at your usual time, apply it as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and continue with your regular application schedule. Do not apply a double quantity to compensate for a missed dose.
Overdose
Topical overdose with Locobase LPL is unlikely to cause serious harm. Applying excessive amounts may increase the risk of local skin irritation, redness, or stinging. If a large amount of the cream is accidentally ingested (for example, by a child), seek medical advice. Propylene glycol can cause gastrointestinal symptoms if ingested in large quantities, though the amount in a tube of cream is generally not sufficient to cause toxicity in adults.
Consult your healthcare provider if your symptoms do not improve or worsen within three weeks of regular use. Also seek advice if you notice new or unusual skin changes that were not present before you began treatment.
What Are the Side Effects of Locobase LPL?
Like all medicines, Locobase LPL can cause side effects, although not everybody gets them. The side effects are predominantly local (at the site of application) and are generally mild and self-limiting. Many patients find that initial irritation decreases as the skin becomes accustomed to the product over the first few days of use.
Common
Affects more than 1 in 100 users
- Skin irritation with a sensation of warmth at the application site
- Stinging or burning feeling upon application, especially on compromised skin
- Mild redness (erythema) at the treated area
Rare
Affects fewer than 1 in 1,000 users
- Allergic reactions (contact dermatitis, itching, rash)
- Delayed hypersensitivity reactions (potentially caused by methylparaben preservative)
Excipient-Related Reactions
In addition to the active ingredient-related side effects listed above, certain excipients (inactive ingredients) in Locobase LPL can occasionally cause skin reactions:
- Cetostearyl alcohol: This emulsifying agent can cause localized skin reactions, most commonly contact eczema. Cetostearyl alcohol allergy is typically identified through patch testing and is distinct from alcohol sensitivity.
- Methylparaben (E218): This preservative can cause allergic reactions that may sometimes be delayed in onset (appearing hours to days after application). Paraben allergy affects approximately 1–3% of dermatitis patients.
Managing Side Effects
The warmth and stinging commonly experienced upon initial application of Locobase LPL is a natural response, particularly when the product is applied to skin with a compromised barrier. This sensation typically subsides within 5–15 minutes and tends to become less noticeable over the first week of regular use. The following strategies can help minimize discomfort:
- Start with once-daily application and gradually increase to twice daily as tolerated.
- Apply to slightly damp skin after bathing to dilute the concentration at the skin surface.
- Avoid applying to areas where the skin is cracked, fissured, or actively inflamed.
- If irritation is persistent or severe, discontinue use and consult your healthcare provider.
Seek medical attention immediately if you experience signs of a severe allergic reaction, including widespread rash, significant swelling (particularly of the face or throat), difficulty breathing, or dizziness. Although extremely rare with topical products, anaphylactic reactions require emergency treatment.
If you experience any side effects not listed here, or if any side effect becomes severe or troublesome, report it to your healthcare provider or pharmacist. You can also report side effects directly to your national pharmacovigilance authority to help improve the safety monitoring of medicines.
How Should You Store Locobase LPL?
Proper storage of Locobase LPL is important to maintain the efficacy and safety of the product throughout its shelf life. The cream is a semi-solid emulsion that can be affected by extreme temperatures, so appropriate storage conditions must be maintained.
- Temperature: Store at a maximum of 25°C (77°F). Avoid exposing the product to excessive heat, direct sunlight, or very cold temperatures. Do not freeze the cream, as freezing can destabilize the emulsion and alter the product's consistency and effectiveness.
- Children: Keep out of the sight and reach of children. Although the product is intended for use in children under supervision, unsupervised access could lead to accidental ingestion.
- Expiry date: Do not use Locobase LPL after the expiry date printed on the packaging (marked as "EXP" or "Use by"). The expiry date refers to the last day of the indicated month.
- After opening: Once opened, use within the timeframe indicated on the packaging. The 100 g tube and 490 g pump container may have different in-use shelf lives — check the packaging for specific guidance.
- Disposal: Do not dispose of medicines via household waste or wastewater. Return unused or expired medicines to your pharmacy for safe disposal. Proper pharmaceutical waste management helps protect the environment.
If you notice any changes in the appearance, smell, or consistency of the cream (such as separation, discoloration, or an unusual odor), do not use the product and consult your pharmacist.
What Does Locobase LPL Contain?
Active Ingredients
| Ingredient | Concentration | Function |
|---|---|---|
| Propylene glycol | 200 mg/g (20%) | Humectant — binds water in the stratum corneum to hydrate and soften the skin |
| Lactic acid | 45 mg/g (4.5%) | Keratolytic (AHA) — breaks down bonds between dead skin cells to promote descaling |
Inactive Ingredients (Excipients)
The following inactive ingredients serve as the cream base and help to stabilize the formulation, improve its texture, and extend its shelf life:
| Ingredient | Function | Notes |
|---|---|---|
| Cetostearyl alcohol | Emulsifier and thickener | May cause contact eczema in sensitive individuals |
| Macrogol cetostearyl ether | Emulsifying agent | Helps stabilize the oil-in-water emulsion |
| Liquid paraffin | Emollient and occlusive | Forms a protective barrier to reduce moisture loss |
| White petroleum jelly (petrolatum) | Occlusive emollient | Seals in moisture and protects the skin |
| Anhydrous citric acid (E330) | pH adjuster | Maintains optimal acidity for lactic acid efficacy |
| Anhydrous sodium citrate | Buffer | Stabilizes pH of the formulation |
| Methylparaben (E218) | Preservative | May cause delayed allergic reactions in sensitive individuals |
| Purified water | Solvent / vehicle | Base of the cream formulation |
Appearance and Packaging
Locobase LPL is a white cream with a smooth, uniform consistency. It is available in two packaging formats:
- 100 g tube — Convenient for travel and targeted application to smaller affected areas.
- 490 g plastic container with dosing pump — Economical option for patients who require widespread or long-term application. The pump mechanism provides hygienic, metered dispensing.
Frequently Asked Questions About Locobase LPL
Locobase LPL is a medicated cream that goes beyond the capabilities of standard moisturizers. While regular moisturizers primarily form a protective barrier on the skin surface (occlusive effect) or provide temporary hydration, Locobase LPL contains two active pharmaceutical ingredients that work at a deeper level. Propylene glycol (200 mg/g) functions as a potent humectant, actively drawing water into the stratum corneum rather than simply sitting on top. Lactic acid (45 mg/g), an alpha-hydroxy acid, acts as a chemical exfoliant that breaks down the bonds between dead skin cells, promoting the shedding of thickened, scaly skin. This dual mechanism makes Locobase LPL particularly effective for conditions like ichthyosis and severe hyperkeratosis, where standard moisturizers are insufficient.
While Locobase LPL is not specifically contraindicated for facial use, caution is advised. The facial skin is thinner and more sensitive than skin on the body, and the combination of propylene glycol and lactic acid may cause more pronounced stinging, redness, or irritation. If you need to treat dry, scaly patches on the face, start with a small test area and apply only a thin layer. Avoid the periorbital area (around the eyes), the lips, and any areas with active inflammation or broken skin. If significant irritation occurs, discontinue facial use and consult your dermatologist about gentler alternatives specifically formulated for facial skin.
Many patients notice improvement in skin hydration and softness within the first few days of regular use. The descaling effect of lactic acid becomes more apparent after 1–2 weeks of consistent application, as the keratolytic action progressively thins the accumulated layer of dead skin cells. For conditions like ichthyosis, maximum clinical benefit is typically observed after 2–4 weeks of twice-daily application. If there is no improvement within three weeks, consult your healthcare provider, as you may need a different treatment approach or additional therapy.
Yes, Locobase LPL is considered safe for long-term use. For chronic skin conditions such as ichthyosis, where the underlying genetic defect causes ongoing skin thickening, regular long-term application is typically necessary to maintain skin health. Propylene glycol and lactic acid do not cause skin thinning (unlike topical corticosteroids) and do not accumulate in the body when applied topically to intact skin. However, it is good practice to have periodic check-ups with your healthcare provider to monitor your skin condition and ensure that the treatment continues to be appropriate for your needs.
The stinging sensation experienced upon applying Locobase LPL is primarily caused by lactic acid, the keratolytic component. As an alpha-hydroxy acid (AHA), lactic acid has a low pH and interacts with nerve endings in the skin, particularly when the skin barrier is compromised (cracked, fissured, or very dry). Propylene glycol can also contribute to the sensation. This is a common and expected response that typically diminishes within 5–15 minutes and tends to become less noticeable after the first few days of regular use as the skin barrier begins to repair. If stinging is severe or persistent, try applying to slightly damp skin or reduce application frequency.
Yes, Locobase LPL is approved for use in children at the same dosage as adults (1–2 times daily). It is commonly used in pediatric dermatology for the management of ichthyosis and other inherited keratinization disorders. However, children may be more sensitive to the stinging effect due to their thinner skin barrier, so it may be helpful to start with once-daily application and increase as tolerated. Young children should have the cream applied by a parent or caregiver, and care should be taken to prevent the child from rubbing the cream into their eyes or mouth. For infants, consult a pediatric dermatologist before starting treatment.
References
All medical information on this page is based on peer-reviewed scientific literature, international clinical guidelines, and official regulatory documentation. The following sources were consulted:
- British Association of Dermatologists (BAD). Guidelines for the Management of Ichthyosis. British Journal of Dermatology, 2023. doi:10.1111/bjd.21776
- American Academy of Dermatology (AAD). Ichthyosis: Diagnosis and Management Guidelines. Journal of the American Academy of Dermatology, 2022.
- Cochrane Database of Systematic Reviews. Emollients and moisturisers for eczema and dry skin conditions: systematic review. Cochrane Library, 2023.
- European Medicines Agency (EMA). Assessment Report on Propylene Glycol Used as an Excipient in Medicinal Products for Human Use. EMA/CHMP/334655/2013, updated 2021. ema.europa.eu
- World Health Organization (WHO). WHO Model List of Essential Medicines – Dermatological Preparations. 23rd edition, 2023.
- National Institute for Health and Care Excellence (NICE). Dry skin conditions: management in primary care. Clinical Knowledge Summaries, updated 2024. cks.nice.org.uk
- Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatologic Therapy. 2004;17(s1):43–48. doi:10.1111/j.1396-0296.2004.04S1005.x
- Oji V, et al. Revised nomenclature and classification of inherited ichthyoses. Journal of the American Academy of Dermatology. 2010;63(4):607–641. doi:10.1016/j.jaad.2009.11.020
- Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology. 2003;4(11):771–788.
- Smith WP. Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology. 1996;35(3):388–391.
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This article has been written and reviewed by our medical editorial team in accordance with international clinical guidelines and peer-reviewed evidence.
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