Koffein Viatris
Caffeine Tablets for Temporary Relief of Fatigue and Drowsiness
Quick Facts About Koffein Viatris
Key Takeaways About Koffein Viatris
- Short-term use only: Koffein Viatris is intended for temporary relief of fatigue and drowsiness, not as a long-term energy supplement or substitute for adequate sleep
- Watch your total caffeine intake: Remember to account for caffeine from all sources (coffee, tea, energy drinks, chocolate) to avoid exceeding safe daily limits of 400 mg for healthy adults
- Caution with heart conditions: People with irregular heart rhythm (arrhythmia) such as sinus tachycardia or ventricular extrasystoles, or those with anxiety disorders, should only use caffeine in low doses and after consulting a doctor
- Withdrawal headache is real: If used regularly over an extended period, stopping suddenly can cause headache, fatigue, and irritability lasting up to 9 days
- Pregnancy limit: Pregnant women should keep total daily caffeine intake below 200–300 mg from all sources combined to minimise potential risks
What Is Koffein Viatris and What Is It Used For?
Koffein Viatris is an over-the-counter caffeine tablet containing 100 mg of caffeine per tablet. It is used to temporarily relieve fatigue and drowsiness by stimulating the central nervous system. Caffeine promotes wakefulness and alertness by blocking adenosine receptors in the brain.
Caffeine is a naturally occurring methylxanthine alkaloid found in coffee beans, tea leaves, cacao pods, and guarana berries. It is the most widely consumed psychoactive substance in the world, with an estimated 80% of the global population consuming caffeine daily in some form. When taken as a tablet such as Koffein Viatris, caffeine provides a standardised, measurable dose that allows for more precise control of intake compared to beverages, which can vary considerably in caffeine content.
The primary mechanism of action of caffeine involves non-selective antagonism of adenosine receptors, particularly the A1 and A2A subtypes, in the central nervous system. Adenosine is a naturally occurring neuromodulator that accumulates in the brain during waking hours and promotes sleepiness by binding to its receptors. By blocking these receptors, caffeine prevents the sleep-promoting effects of adenosine, resulting in increased wakefulness, improved concentration, enhanced alertness, and a reduced perception of fatigue.
At higher concentrations, caffeine also inhibits phosphodiesterase enzymes, which leads to increased intracellular levels of cyclic adenosine monophosphate (cAMP). This secondary mechanism contributes to caffeine's stimulatory effects on the cardiovascular system, including mild increases in heart rate and blood pressure. Caffeine also stimulates the release of catecholamines (adrenaline and noradrenaline) from the adrenal medulla, further enhancing its alerting and stimulatory properties.
In terms of clinical use, Koffein Viatris is indicated for temporary fatigue – situations where short-term wakefulness is needed, such as during periods of prolonged driving, studying, or shift work. It is important to emphasise that caffeine tablets are not a substitute for adequate sleep. The European Food Safety Authority (EFSA) has confirmed that a cause-and-effect relationship exists between caffeine intake (at least 75 mg) and increased attention and alertness in healthy adults. However, EFSA also notes that habitual caffeine consumption may lead to tolerance, meaning that higher doses are needed over time to achieve the same stimulatory effect.
After oral administration, caffeine is rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are typically reached within 30 to 60 minutes. The plasma half-life of caffeine in healthy adults ranges from 3 to 7 hours, though this can be significantly prolonged in pregnant women (up to 15 hours in the third trimester), in people with liver disease, and in individuals taking certain medications that inhibit the CYP1A2 enzyme. Caffeine freely crosses the blood-brain barrier and the placental barrier.
What Should You Know Before Taking Koffein Viatris?
Before using Koffein Viatris, be aware of your total daily caffeine intake from all sources. Avoid this medication if you are allergic to caffeine. Use with caution if you have heart rhythm disorders (arrhythmia) or anxiety disorders, as caffeine may worsen these conditions.
Contraindications
You should not take Koffein Viatris if:
- Allergy to caffeine or any of the other ingredients in this product (magnesium stearate, gelatin, potato starch, sodium starch glycolate) – although true caffeine allergy is extremely rare, hypersensitivity reactions can include skin rash, itching, or in very rare cases, breathing difficulties
True caffeine allergy is exceptionally uncommon and should be distinguished from caffeine sensitivity (intolerance), in which individuals experience exaggerated stimulatory effects such as jitteriness, rapid heart rate, and insomnia at relatively low doses. If you suspect a caffeine allergy, consult an allergist for proper testing.
Warnings and Precautions
Talk to your doctor, pharmacist, or nurse before using Koffein Viatris if you have any of the following conditions:
- Irregular heart rhythm (cardiac arrhythmia) – such as sinus tachycardia or ventricular extrasystoles. Caffeine can increase heart rate and may trigger or worsen cardiac arrhythmias. If you have a known heart rhythm disorder, you should only use caffeine in low doses and under medical guidance
- Anxiety disorders – caffeine stimulates the sympathetic nervous system and can exacerbate symptoms of generalised anxiety disorder, panic disorder, and social anxiety. People with anxiety disorders may be particularly sensitive to the anxiogenic effects of caffeine, even at moderate doses
- Gastroesophageal reflux disease (GERD) – caffeine can relax the lower oesophageal sphincter and stimulate gastric acid secretion, potentially worsening heartburn and reflux symptoms
- Peptic ulcer disease – caffeine stimulates gastric acid secretion and may aggravate ulcer symptoms
- Insomnia or sleep disorders – caffeine's stimulatory effects can last 3 to 7 hours or longer. Avoid taking caffeine tablets in the late afternoon or evening
- High blood pressure (hypertension) – caffeine can cause a temporary increase in blood pressure, particularly in individuals who do not consume caffeine regularly. If you have uncontrolled hypertension, consult your doctor before using caffeine tablets
You should also limit concurrent intake of other caffeine-containing products while using Koffein Viatris. This includes coffee, tea, cola, energy drinks, chocolate, and other medications that contain caffeine. The total daily caffeine intake from all sources should generally not exceed 400 mg for healthy adults, according to guidelines from the European Food Safety Authority (EFSA) and the U.S. Food and Drug Administration (FDA).
Pregnancy and Breastfeeding
If you are pregnant, breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before using this medication.
Pregnancy: Higher doses of caffeine during pregnancy may be associated with an increased risk of miscarriage, though a definitive causal relationship has not been conclusively established. The World Health Organization (WHO) and several national health authorities recommend that pregnant women limit their total daily caffeine intake to no more than 200–300 mg from all sources, including coffee, tea, chocolate, energy drinks, and caffeine tablets. A single cup of brewed coffee typically contains 80–120 mg of caffeine. The half-life of caffeine is significantly prolonged during pregnancy (up to 15 hours in the third trimester), meaning that caffeine accumulates in the body more readily.
Breastfeeding: Caffeine passes into breast milk but is unlikely to affect the nursing infant at moderate maternal intake levels. However, newborns and young infants metabolise caffeine much more slowly than adults (half-life of up to 100 hours in neonates compared to 3–7 hours in adults). If you consume large amounts of caffeine while breastfeeding, your baby may become irritable or have difficulty sleeping. Consult your doctor if you plan to use Koffein Viatris regularly while breastfeeding.
Driving and Operating Machinery
Koffein Viatris has no known adverse effects on the ability to drive or operate machinery when used as directed. In fact, caffeine may improve alertness and reaction time, which can be beneficial for drivers experiencing temporary fatigue. However, you should be aware that caffeine is not a substitute for rest, and its effects wear off over time. The European Transport Safety Council notes that caffeine may provide a short-term benefit for drowsy drivers, but pulling over and taking a 15–20 minute nap is more effective for sustained alertness.
You are responsible for assessing your own fitness to drive or perform tasks requiring alertness. Caffeine can mask true fatigue without eliminating the underlying sleep debt, potentially giving a false sense of alertness.
Sodium Content
This medicine contains less than 1 mmol (23 mg) of sodium per tablet, meaning it is essentially sodium-free. This is relevant for patients on a sodium-restricted diet.
How Does Koffein Viatris Interact with Other Drugs?
Caffeine interacts with several medications including adenosine (used in cardiac testing), certain antibiotics (ciprofloxacin, norfloxacin), the antidepressant fluvoxamine, and psychiatric medications such as clozapine and lithium. Always inform your doctor about your caffeine intake, including tablets, coffee, and energy drinks.
Caffeine is primarily metabolised in the liver by the cytochrome P450 enzyme CYP1A2, which converts it to paraxanthine (about 84%), theobromine (about 12%), and theophylline (about 4%). Drugs that inhibit CYP1A2 can dramatically increase caffeine blood levels and prolong its effects, while CYP1A2 inducers can reduce caffeine's efficacy. Additionally, caffeine itself can alter the blood levels and effects of certain other drugs.
Major Interactions
| Drug | Category | Effect | Recommendation |
|---|---|---|---|
| Adenosine | Cardiac diagnostic/therapeutic agent | Caffeine directly antagonises adenosine receptors, significantly reducing or completely blocking the effects of adenosine used in cardiac stress testing or for treatment of supraventricular tachycardia | Stop all caffeine intake at least 12–24 hours before adenosine administration |
| Fluvoxamine | Antidepressant (SSRI) | Potent CYP1A2 inhibitor that can increase caffeine levels by up to 5-fold, dramatically prolonging caffeine half-life | Significantly reduce or eliminate caffeine intake; monitor for caffeine toxicity symptoms |
| Clozapine | Antipsychotic (schizophrenia) | Both caffeine and clozapine are metabolised by CYP1A2; caffeine can increase clozapine blood levels, raising the risk of serious side effects | Maintain consistent caffeine intake; sudden changes may require clozapine dose adjustment |
| Lithium | Mood stabiliser (bipolar disorder) | Caffeine increases renal clearance of lithium, potentially reducing lithium blood levels and therapeutic effectiveness | Keep caffeine intake consistent; sudden increases or decreases may alter lithium levels |
Moderate Interactions
| Drug | Category | Effect | Recommendation |
|---|---|---|---|
| Ciprofloxacin / Norfloxacin | Fluoroquinolone antibiotics | CYP1A2 inhibitors that increase caffeine levels by 40–70%, prolonging its stimulatory effects | Reduce caffeine intake during antibiotic treatment; monitor for insomnia and restlessness |
| Phenylpropanolamine | Decongestant / appetite suppressant | Additive cardiovascular stimulation; combined use may cause significant blood pressure elevation | Avoid concurrent use or use with caution; monitor blood pressure |
| Carbamazepine | Anticonvulsant (epilepsy) | Carbamazepine is a CYP1A2 inducer that may reduce caffeine effectiveness; caffeine may also lower the seizure threshold | Use with caution in epilepsy patients; consult your neurologist |
| Theophylline | Bronchodilator (asthma/COPD) | Caffeine is structurally related to theophylline; both compete for CYP1A2 metabolism, potentially increasing theophylline levels and toxicity risk | Limit caffeine intake; monitor for theophylline side effects (nausea, tremor, tachycardia) |
| Ephedrine / Pseudoephedrine | Sympathomimetic decongestants | Additive cardiovascular stimulation; may increase heart rate and blood pressure | Use with caution; avoid high doses of caffeine during concurrent use |
In addition to the interactions listed above, you should be aware that concurrent use of other caffeine-containing products – including coffee, tea, cola, energy drinks, and caffeine-containing medications (such as some analgesics and cold remedies) – can result in cumulative caffeine intake that exceeds safe levels. Always read product labels carefully and calculate your total daily caffeine consumption from all sources.
What Is the Correct Dosage of Koffein Viatris?
The recommended dose is 1–2 tablets (100–200 mg) taken 1 to 3 times per day. Do not exceed the recommended dose as this increases the risk of side effects and caffeine toxicity. Always take this medicine exactly as described in the package leaflet or as directed by your doctor or pharmacist.
Always use Koffein Viatris exactly as described in the patient information leaflet or as instructed by your doctor or pharmacist. If you are unsure, ask your doctor or pharmacist for clarification. The tablets should be swallowed with water and can be taken with or without food.
Adults
Temporary Fatigue and Drowsiness
Standard dose: 1–2 tablets (100–200 mg) per dose
Frequency: 1 to 3 times per day
Maximum daily dose: 6 tablets (600 mg)
The onset of action is typically 15–45 minutes after oral administration, with peak effects occurring within 30–60 minutes. The duration of effect is approximately 3–5 hours, depending on individual metabolism. It is advisable to start with the lowest effective dose (100 mg) and increase only if necessary.
The European Food Safety Authority (EFSA) recommends that healthy adults consume no more than 400 mg of caffeine per day from all sources. A standard cup of filtered coffee contains approximately 80–120 mg of caffeine, a cup of tea contains 30–50 mg, and a 250 ml energy drink typically contains 80 mg. When using Koffein Viatris, you must account for caffeine from all dietary sources to stay within safe limits.
Children and Adolescents
Not Recommended
Koffein Viatris is not recommended for children and adolescents. The European Food Safety Authority advises that children and adolescents limit caffeine intake to no more than 3 mg per kg body weight per day. For a child weighing 30 kg, this equates to a maximum of 90 mg per day – less than a single Koffein Viatris tablet. Children are more sensitive to caffeine's stimulatory effects and are more likely to experience adverse effects such as anxiety, sleep disturbance, and increased heart rate.
Elderly Patients
No specific dose adjustment is required for elderly patients. However, older adults may be more sensitive to the cardiovascular and central nervous system effects of caffeine. Caffeine clearance may be slightly reduced with age, and elderly individuals are more likely to have co-existing conditions (such as cardiac arrhythmias, hypertension, or insomnia) that can be exacerbated by caffeine. It is prudent for elderly patients to start with the lowest effective dose and to be mindful of total daily caffeine intake from all sources.
Missed Dose
Koffein Viatris is used on an as-needed basis for temporary fatigue, so there is no regular dosing schedule that would make a missed dose relevant. Simply take it when you need it, without exceeding the maximum recommended daily dose. Do not take a double dose to compensate for a previously missed one.
Overdose
Taking too much caffeine can cause serious and potentially life-threatening symptoms. Mild caffeine overdose (above 600 mg) may produce agitation, restlessness, nausea, vomiting, rapid heart rate, and tremor. Severe caffeine overdose (above 1,200 mg) can cause seizures, cardiac arrhythmias, metabolic acidosis, hypokalaemia, rhabdomyolysis, and in extreme cases, death. The estimated lethal dose of caffeine in adults is approximately 10–14 grams (100–140 tablets of Koffein Viatris). If you or someone else has taken an excessive amount of caffeine tablets, contact emergency services or your local poison control centre immediately. In the case of children accidentally ingesting caffeine tablets, seek medical attention without delay.
Stopping and Withdrawal
If Koffein Viatris (or caffeine from any source) has been used regularly over an extended period, abrupt discontinuation can cause withdrawal symptoms. The most characteristic withdrawal symptom is headache, which typically begins 12–24 hours after the last caffeine dose, peaks at 20–51 hours, and can last up to 9 days. Other withdrawal symptoms may include fatigue, decreased energy, difficulty concentrating, depressed mood, irritability, and flu-like symptoms (muscle aches and stiffness).
Caffeine withdrawal is recognised by the World Health Organization (ICD-10 code F15.3) and the American Psychiatric Association (DSM-5). To minimise withdrawal effects, it is advisable to gradually reduce caffeine intake over a period of days to weeks rather than stopping abruptly.
What Are the Side Effects of Koffein Viatris?
Common side effects of Koffein Viatris include nausea, restlessness, insomnia, headache, increased urination, palpitations (rapid heartbeat), and tremor. These affect up to 1 in 10 users. Uncommon or rare side effects include premature heartbeats (extrasystoles), tinnitus, and visual flickering.
Like all medicines, Koffein Viatris can cause side effects, although not everybody experiences them. The likelihood and severity of side effects are dose-dependent – higher doses and individual sensitivity to caffeine both increase the risk. People who do not regularly consume caffeine (caffeine-naïve individuals) are more likely to experience side effects compared to habitual caffeine consumers who have developed tolerance.
Common
May affect up to 1 in 10 people
- Nausea
- Restlessness and anxiety
- Insomnia (difficulty sleeping)
- Headache
- Increased urination (diuresis)
- Increased heart rate (palpitations / tachycardia)
- Tremor (fine hand trembling)
Uncommon to Rare
May affect up to 1 in 1,000 people
- Premature heartbeats (cardiac extrasystoles)
- Tinnitus (ringing in the ears)
- Visual flickering (photopsia)
In addition to the side effects listed above, chronic excessive caffeine consumption (typically above 600 mg per day) can lead to a condition known as caffeinism, characterised by persistent anxiety, agitation, insomnia, gastrointestinal disturbances, muscle twitching, rambling flow of thought and speech, and periods of inexhaustibility. These symptoms typically resolve when caffeine intake is reduced to moderate levels.
Caffeine also has well-documented effects on the gastrointestinal system. It stimulates gastric acid secretion and can cause or worsen symptoms of gastroesophageal reflux disease (GERD). It has a mild laxative effect due to stimulation of colonic motility. Some individuals experience abdominal discomfort, stomach cramps, or diarrhoea, particularly when consuming caffeine on an empty stomach.
The cardiovascular effects of caffeine are generally mild at recommended doses. Caffeine causes a transient increase in blood pressure (typically 5–10 mmHg systolic) and heart rate. In most healthy individuals, these effects are clinically insignificant and diminish with regular use (tolerance). However, in susceptible individuals – particularly those with pre-existing arrhythmias – caffeine may precipitate or worsen palpitations, premature ventricular contractions, or other rhythm disturbances.
If you experience any side effects, talk to your doctor or pharmacist. You can also report suspected side effects directly to your national pharmacovigilance authority. By reporting side effects, you help to provide more information on the benefit-risk profile of this medicine.
How Should You Store Koffein Viatris?
Store Koffein Viatris out of the sight and reach of children. Do not use after the expiry date stated on the label (EXP). The expiry date refers to the last day of that month. No special storage temperature conditions are required.
Keep this medicine in its original packaging in order to protect it from moisture and light. Store it in a dry place at room temperature (below 25°C / 77°F). Do not store in the bathroom or near a sink, as humidity can degrade the tablets.
It is especially important to keep caffeine tablets out of the sight and reach of children. Accidental ingestion of multiple caffeine tablets by a young child can lead to serious caffeine toxicity, including seizures and cardiac arrhythmias. If a child accidentally swallows caffeine tablets, contact your local poison control centre or emergency services immediately.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help protect the environment and ensure that discarded medication does not pose a risk to others.
What Does Koffein Viatris Contain?
Each Koffein Viatris tablet contains 100 mg of caffeine as the active ingredient. The other ingredients are magnesium stearate, gelatin, potato starch, and sodium starch glycolate. The tablets are white, flat, scored, and 8 mm in diameter.
Active Ingredient
The active substance is caffeine 100 mg per tablet. Caffeine (1,3,7-trimethylxanthine) is a white, odourless, bitter-tasting crystalline powder with a molecular weight of 194.19 g/mol. It is freely soluble in hot water and slightly soluble in cold water.
Other Ingredients (Excipients)
- Magnesium stearate – a lubricant that prevents the tablet from sticking to the manufacturing equipment during compression
- Gelatin – a binding agent derived from collagen that helps hold the tablet together
- Potato starch – a disintegrant and filler that helps the tablet break apart in the gastrointestinal tract for proper absorption
- Sodium starch glycolate – a superdisintegrant that ensures rapid disintegration of the tablet in the stomach
Appearance and Pack Sizes
Koffein Viatris is a white, flat tablet with a score line and a diameter of 8 mm. The score line allows the tablet to be divided into two equal halves, enabling a dose of 50 mg if a lower dose is desired. The tablets are supplied in a plastic container containing 30 tablets.
Marketing Authorisation Holder
The marketing authorisation for Koffein Viatris is held by Viatris, a global pharmaceutical and healthcare company formed through the combination of Mylan and Upjohn. The tablets are manufactured by Sidefarma – Sociedade Industrial de Expansão Farmacêutica S.A. in Prior Velho, Portugal.
Frequently Asked Questions About Koffein Viatris
The primary difference is dosing precision. A Koffein Viatris tablet delivers exactly 100 mg of caffeine, whereas a cup of coffee can contain anywhere from 50 to 200 mg depending on the brewing method, bean type, and serving size. Coffee also contains hundreds of other bioactive compounds (including chlorogenic acids, diterpenes, and antioxidants) that caffeine tablets do not. Some of these compounds may have additional health effects – both positive and negative – that are not present with pure caffeine. From a pharmacological standpoint, the caffeine from tablets and from coffee produces the same physiological effects at equivalent doses.
The stimulatory effects of a 100 mg caffeine tablet typically begin within 15–45 minutes of ingestion and last approximately 3–5 hours. However, the plasma half-life of caffeine varies widely between individuals: 3–7 hours in healthy adults, shorter in smokers (approximately 3 hours due to CYP1A2 induction), and significantly longer in pregnant women (up to 15 hours in the third trimester), in people with liver disease, and in those taking CYP1A2 inhibitors. It is generally advisable to avoid taking caffeine tablets within 6 hours of bedtime to prevent sleep disturbance.
At recommended doses, caffeine is generally considered safe for the cardiovascular system in healthy individuals. It causes a mild, transient increase in blood pressure and heart rate that is clinically insignificant in most people. However, in susceptible individuals – particularly those with pre-existing arrhythmias, certain genetic variants affecting caffeine metabolism, or underlying structural heart disease – caffeine may trigger or worsen palpitations, premature ventricular contractions, or supraventricular tachycardia. If you have any heart condition, consult your cardiologist before using caffeine tablets. Large epidemiological studies have not found that moderate caffeine consumption (up to 400 mg/day) increases the risk of coronary heart disease, heart failure, or atrial fibrillation in the general population.
Combining caffeine tablets with energy drinks is strongly discouraged because it can easily lead to excessive caffeine intake. A single 250 ml energy drink typically contains 80 mg of caffeine, and larger cans may contain 150–300 mg. Adding Koffein Viatris tablets on top of energy drink consumption can quickly push your total daily intake well above the recommended 400 mg limit for healthy adults. Excessive caffeine intake increases the risk of anxiety, insomnia, palpitations, gastrointestinal distress, and in severe cases, cardiac arrhythmias and seizures. Always calculate your total caffeine intake from all sources.
Koffein Viatris is intended for temporary, occasional use to combat short-term fatigue. While moderate daily caffeine consumption (up to 400 mg from all sources) is generally considered safe for most healthy adults according to EFSA and FDA guidelines, regular daily use of caffeine tablets can lead to tolerance (needing progressively higher doses for the same effect) and physical dependence (experiencing withdrawal symptoms upon discontinuation). If you find yourself needing caffeine tablets every day to function, this may indicate an underlying sleep disorder, chronic fatigue, or other medical condition that should be evaluated by a healthcare professional.
If you have taken more Koffein Viatris tablets than recommended, or if a child has accidentally swallowed caffeine tablets, contact your local poison control centre or emergency services immediately. Symptoms of caffeine overdose include severe restlessness, agitation, nausea, vomiting, rapid heartbeat, tremor, and in serious cases seizures. Do not attempt to induce vomiting unless specifically instructed to do so by a healthcare professional or poison control. Provide the healthcare team with as much information as possible: how many tablets were taken, when they were taken, and the person's age and weight.
References and Sources
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- European Medicines Agency (EMA). Guideline on the Investigation of Drug Interactions. CPMP/EWP/560/95/Rev.1 Corr.2, 2012.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Caffeine-Related Disorders (Section 305.90). Arlington, VA: APA; 2013.
- British National Formulary (BNF). Caffeine Citrate. NICE Evidence Services, 2025.
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Editorial Team
This article has been developed by the iMedic Medical Editorial Team and reviewed by specialist physicians with expertise in clinical pharmacology and toxicology.
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