NMDA receptor antagonist: Class Overview and Comparison
Quick answer: NMDA receptor antagonist are a class of medicines used for specific therapeutic indications. iMedic covers 5 nmda receptor antagonist substances. Below is a comparison table linking to detailed pages for each.
NMDA receptor antagonist on iMedic (5 substances)
| Substance | Primary indications | Mechanism | Common dose |
|---|---|---|---|
| Axura | Moderate to severe Alzheimer's disease | Memantine is a non-competitive NMDA receptor antagonist that reduces excitotoxic | 5-20 mg daily, titrated weekly |
| Ebixa | Moderate-to-severe Alzheimer's disease | Memantine is a low-affinity, voltage-dependent NMDA receptor antagonist that red | 5-20 mg daily (titrated weekly) |
| Marixino | Moderate to severe Alzheimer's disease | Non-competitive NMDA receptor antagonist that modulates glutamate-mediated excit | 5-20 mg once daily |
| Memantine | Moderate to severe Alzheimer's disease | Non-competitive NMDA receptor antagonist that reduces glutamatergic excitotoxici | 5-20 mg daily (titrated) |
| Nemdatine | Moderate to severe Alzheimer's disease | Non-competitive NMDA receptor antagonist reducing glutamate-mediated excitotoxic | 5-20 mg/day orally |
About NMDA receptor antagonist
NMDA receptor antagonist share a common mechanism of action and clinical use. Specific dosing, side effects, contraindications, and drug interactions vary between individual substances within the class. Click any substance above for full prescribing information and patient guidance.
Common considerations across the class
- Indication-specific selection: Different members may be preferred for different conditions or patient populations
- Dose equivalence: Members of the same class are not always interchangeable on a 1:1 dose basis
- Drug interactions: Class members often share interaction profiles (e.g., CYP enzyme effects) but individual variation matters
- Side effects: Some side effects are class-wide; others are substance-specific
- Contraindications: Individual contraindications may not generalize across the class
Always consult the prescribing information for the specific medicine prescribed and discuss with your clinician.
Frequently asked questions
What are NMDA receptor antagonist?
NMDA receptor antagonist are medicines that share a common mechanism of action used for specific therapeutic indications. iMedic currently covers 5 substances in this class with detailed pages for each.
Are all NMDA receptor antagonist interchangeable?
No. While medicines in the same class share a mechanism, they differ in potency, dosing, drug interactions, and tolerability. Switching between them is a clinical decision based on individual response, side effects, and treatment goals.
How do I choose between different NMDA receptor antagonist?
Selection depends on the specific clinical indication, patient factors (age, comorbidities, kidney/liver function, other medications), tolerability of side effects, cost, and clinician preference. This is a prescribing decision.
Are NMDA receptor antagonist available as generics?
Most well-established class members are available as generic alternatives, often substantially less expensive than brand-name versions while clinically equivalent. Newer members may still be brand-only.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.