Long-acting muscarinic antagonist (LAMA): Class Overview and Comparison
Quick answer: Long-acting muscarinic antagonist (LAMA) are a class of medicines used for specific therapeutic indications. iMedic covers 6 long-acting muscarinic antagonist (lama) substances. Below is a comparison table linking to detailed pages for each.
Long-acting muscarinic antagonist (LAMA) on iMedic (6 substances)
| Substance | Primary indications | Mechanism | Common dose |
|---|---|---|---|
| Bretaris Genuair | Chronic obstructive pulmonary disease (COPD) | Brand name for aclidinium bromide via Genuair inhaler; long-acting anticholinerg | 322 mcg (one inhalation) twice daily |
| Eklira Genuair | Chronic obstructive pulmonary disease (COPD) | Inhaled anticholinergic that blocks muscarinic M3 receptors to produce bronchodi | 322 mcg (one inhalation) twice daily |
| Enurev Breezhaler | Chronic obstructive pulmonary disease (COPD) | Inhaled long-acting muscarinic receptor antagonist causing bronchodilation | 44 mcg once daily via Breezhaler inhaler |
| Incruse Ellipta | Chronic obstructive pulmonary disease (COPD) | Long-acting anticholinergic that blocks muscarinic M3 receptors causing bronchod | 55 mcg inhaled once daily |
| Rolufta Ellipta | Chronic obstructive pulmonary disease (COPD) | Selective long-acting muscarinic receptor antagonist producing bronchodilation | 55 micrograms once daily via inhalation |
| Tiotropium | COPD, Asthma | Long-acting anticholinergic that blocks M3 muscarinic receptors causing bronchod | 18 mcg inhaled once daily (HandiHaler) or 2.5 mcg x2 puffs (Respimat) |
About Long-acting muscarinic antagonist (LAMA)
Long-acting muscarinic antagonist (LAMA) share a common mechanism of action and clinical use. Specific dosing, side effects, contraindications, and drug interactions vary between individual substances within the class. Click any substance above for full prescribing information and patient guidance.
Common considerations across the class
- Indication-specific selection: Different members may be preferred for different conditions or patient populations
- Dose equivalence: Members of the same class are not always interchangeable on a 1:1 dose basis
- Drug interactions: Class members often share interaction profiles (e.g., CYP enzyme effects) but individual variation matters
- Side effects: Some side effects are class-wide; others are substance-specific
- Contraindications: Individual contraindications may not generalize across the class
Always consult the prescribing information for the specific medicine prescribed and discuss with your clinician.
Frequently asked questions
What are Long-acting muscarinic antagonist (LAMA)?
Long-acting muscarinic antagonist (LAMA) are medicines that share a common mechanism of action used for specific therapeutic indications. iMedic currently covers 6 substances in this class with detailed pages for each.
Are all Long-acting muscarinic antagonist (LAMA) interchangeable?
No. While medicines in the same class share a mechanism, they differ in potency, dosing, drug interactions, and tolerability. Switching between them is a clinical decision based on individual response, side effects, and treatment goals.
How do I choose between different Long-acting muscarinic antagonist (LAMA)?
Selection depends on the specific clinical indication, patient factors (age, comorbidities, kidney/liver function, other medications), tolerability of side effects, cost, and clinician preference. This is a prescribing decision.
Are Long-acting muscarinic antagonist (LAMA) available as generics?
Most well-established class members are available as generic alternatives, often substantially less expensive than brand-name versions while clinically equivalent. Newer members may still be brand-only.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.