GnRH agonist: Class Overview and Comparison
Quick answer: GnRH agonist are a class of medicines used for specific therapeutic indications. iMedic covers 5 gnrh agonist substances. Below is a comparison table linking to detailed pages for each.
GnRH agonist on iMedic (5 substances)
| Substance | Primary indications | Mechanism | Common dose |
|---|---|---|---|
| Eligard | Advanced prostate cancer | Leuprolide acetate is a GnRH agonist that suppresses pituitary gonadotropin secr | 7.5 mg monthly, 22.5 mg q3 months, 30 mg q4 months, or 45 mg q6 months SC |
| Pamorelin | Prostate cancer, Endometriosis | Synthetic GnRH analog that suppresses gonadotropin and sex hormone production af | 3.75 mg monthly, 11.25 mg every 3 months, or 22.5 mg every 6 months IM |
| Suprefact | Prostate cancer, Endometriosis | Buserelin — gonadotropin-releasing hormone agonist that initially stimulates the | Nasal spray 300 mcg three times daily; or 500 mcg SC three times daily for 7 days then 200 mcg daily |
| Suprefact Depot | Prostate cancer | Buserelin depot formulation — long-acting GnRH agonist that downregulates pituit | 6.3 mg implant every 2 months or 9.45 mg implant every 3 months |
| Synarela | Endometriosis, Central precocious puberty | Gonadotropin-releasing hormone agonist that suppresses pituitary gonadotropin se | 200 mcg intranasally twice daily |
About GnRH agonist
GnRH agonist share a common mechanism of action and clinical use. Specific dosing, side effects, contraindications, and drug interactions vary between individual substances within the class. Click any substance above for full prescribing information and patient guidance.
Common considerations across the class
- Indication-specific selection: Different members may be preferred for different conditions or patient populations
- Dose equivalence: Members of the same class are not always interchangeable on a 1:1 dose basis
- Drug interactions: Class members often share interaction profiles (e.g., CYP enzyme effects) but individual variation matters
- Side effects: Some side effects are class-wide; others are substance-specific
- Contraindications: Individual contraindications may not generalize across the class
Always consult the prescribing information for the specific medicine prescribed and discuss with your clinician.
Frequently asked questions
What are GnRH agonist?
GnRH agonist are medicines that share a common mechanism of action used for specific therapeutic indications. iMedic currently covers 5 substances in this class with detailed pages for each.
Are all GnRH agonist interchangeable?
No. While medicines in the same class share a mechanism, they differ in potency, dosing, drug interactions, and tolerability. Switching between them is a clinical decision based on individual response, side effects, and treatment goals.
How do I choose between different GnRH agonist?
Selection depends on the specific clinical indication, patient factors (age, comorbidities, kidney/liver function, other medications), tolerability of side effects, cost, and clinician preference. This is a prescribing decision.
Are GnRH agonist available as generics?
Most well-established class members are available as generic alternatives, often substantially less expensive than brand-name versions while clinically equivalent. Newer members may still be brand-only.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.