Fluoroquinolone antibiotic: Class Overview and Comparison
Quick answer: Fluoroquinolone antibiotic are a class of medicines used for specific therapeutic indications. iMedic covers 5 fluoroquinolone antibiotic substances. Below is a comparison table linking to detailed pages for each.
Fluoroquinolone antibiotic on iMedic (5 substances)
| Substance | Primary indications | Mechanism | Common dose |
|---|---|---|---|
| Ciprofloxacin | Urinary tract infections, Respiratory tract infections | Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication | 250-750 mg orally twice daily or 200-400 mg IV every 8-12 hours |
| Levofloxacin | Pneumonia, Urinary tract infections | Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication | 250-750 mg once daily |
| Moxifloxacin | Community-acquired pneumonia, Acute bacterial sinusitis | Inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication and | 400 mg once daily orally or IV |
| Ofloxacin Mibe | Urinary tract infections, Respiratory tract infections | Inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication | 200-400 mg twice daily |
| Quofenix | Acute bacterial skin and skin structure infections, Community-acquired bacterial pneumonia | Delafloxacin inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA re | 300 mg IV every 12 hours or 450 mg orally every 12 hours |
About Fluoroquinolone antibiotic
Fluoroquinolone antibiotic share a common mechanism of action and clinical use. Specific dosing, side effects, contraindications, and drug interactions vary between individual substances within the class. Click any substance above for full prescribing information and patient guidance.
Common considerations across the class
- Indication-specific selection: Different members may be preferred for different conditions or patient populations
- Dose equivalence: Members of the same class are not always interchangeable on a 1:1 dose basis
- Drug interactions: Class members often share interaction profiles (e.g., CYP enzyme effects) but individual variation matters
- Side effects: Some side effects are class-wide; others are substance-specific
- Contraindications: Individual contraindications may not generalize across the class
Always consult the prescribing information for the specific medicine prescribed and discuss with your clinician.
Frequently asked questions
What are Fluoroquinolone antibiotic?
Fluoroquinolone antibiotic are medicines that share a common mechanism of action used for specific therapeutic indications. iMedic currently covers 5 substances in this class with detailed pages for each.
Are all Fluoroquinolone antibiotic interchangeable?
No. While medicines in the same class share a mechanism, they differ in potency, dosing, drug interactions, and tolerability. Switching between them is a clinical decision based on individual response, side effects, and treatment goals.
How do I choose between different Fluoroquinolone antibiotic?
Selection depends on the specific clinical indication, patient factors (age, comorbidities, kidney/liver function, other medications), tolerability of side effects, cost, and clinician preference. This is a prescribing decision.
Are Fluoroquinolone antibiotic available as generics?
Most well-established class members are available as generic alternatives, often substantially less expensive than brand-name versions while clinically equivalent. Newer members may still be brand-only.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.