Dopamine agonist (non-ergot): Class Overview and Comparison
Quick answer: Dopamine agonist (non-ergot) are a class of medicines used for specific therapeutic indications. iMedic covers 7 dopamine agonist (non-ergot) substances. Below is a comparison table linking to detailed pages for each.
Dopamine agonist (non-ergot) on iMedic (7 substances)
| Substance | Primary indications | Mechanism | Common dose |
|---|---|---|---|
| Apo Go | Parkinson's disease motor fluctuations, Off-episodes in advanced Parkinson's | Apomorphine — non-selective dopamine D1/D2 receptor agonist providing rapid moto | 2-10 mg subcutaneous injection per off-episode |
| Apo Go Fr Pod | Parkinson's disease motor fluctuations, Off-episodes in advanced Parkinson's | Apomorphine pre-filled cartridge for continuous subcutaneous infusion | 1-4 mg/hour continuous subcutaneous infusion |
| Apo Go Pen | Parkinson's disease motor fluctuations, Off-episodes in advanced Parkinson's | Apomorphine pre-filled pen injector for rapid rescue of off-episodes | 2-10 mg subcutaneous injection per off-episode |
| Mirapexin | Parkinson's disease, Restless legs syndrome | Pramipexole is a non-ergoline dopamine D2/D3 receptor agonist | 0.375-4.5 mg daily (immediate release, divided) |
| Neupro | Parkinson's disease, Restless legs syndrome | Rotigotine; non-ergoline dopamine agonist with activity at D1, D2, and D3 recept | 1-16 mg/24h transdermal patch daily |
| Oprymea | Parkinson's disease, Restless legs syndrome | Selective D2/D3 dopamine receptor agonist (pramipexole) stimulating striatal dop | 0.375-4.5 mg daily in divided doses (Parkinson's); 0.088-0.54 mg once daily (RLS) |
| Pramipexol | Parkinson's disease, Restless legs syndrome | Selective D2/D3 dopamine receptor agonist that stimulates dopaminergic neurotran | 0.375-4.5 mg/day in divided doses (immediate-release) |
About Dopamine agonist (non-ergot)
Dopamine agonist (non-ergot) share a common mechanism of action and clinical use. Specific dosing, side effects, contraindications, and drug interactions vary between individual substances within the class. Click any substance above for full prescribing information and patient guidance.
Common considerations across the class
- Indication-specific selection: Different members may be preferred for different conditions or patient populations
- Dose equivalence: Members of the same class are not always interchangeable on a 1:1 dose basis
- Drug interactions: Class members often share interaction profiles (e.g., CYP enzyme effects) but individual variation matters
- Side effects: Some side effects are class-wide; others are substance-specific
- Contraindications: Individual contraindications may not generalize across the class
Always consult the prescribing information for the specific medicine prescribed and discuss with your clinician.
Frequently asked questions
What are Dopamine agonist (non-ergot)?
Dopamine agonist (non-ergot) are medicines that share a common mechanism of action used for specific therapeutic indications. iMedic currently covers 7 substances in this class with detailed pages for each.
Are all Dopamine agonist (non-ergot) interchangeable?
No. While medicines in the same class share a mechanism, they differ in potency, dosing, drug interactions, and tolerability. Switching between them is a clinical decision based on individual response, side effects, and treatment goals.
How do I choose between different Dopamine agonist (non-ergot)?
Selection depends on the specific clinical indication, patient factors (age, comorbidities, kidney/liver function, other medications), tolerability of side effects, cost, and clinician preference. This is a prescribing decision.
Are Dopamine agonist (non-ergot) available as generics?
Most well-established class members are available as generic alternatives, often substantially less expensive than brand-name versions while clinically equivalent. Newer members may still be brand-only.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.