Sacubitril Valsartan and Spironolactone: Drug Interaction Guide
Quick answer: This combination requires caution. Sacubitril Valsartan and Spironolactone can be used together with adjustments and monitoring.
How Sacubitril Valsartan interacts with Spironolactone
Both drugs raise serum potassium — sacubitril/valsartan via angiotensin receptor blockade, spironolactone via aldosterone antagonism — with additive risk of clinically significant hyperkalaemia.
What you should do
Check potassium and renal function within 1-2 weeks of starting or up-titrating, then every 4 months. Avoid potassium supplements and salt substitutes.
Key facts
Severity
Moderate — caution required
Mechanism
Both drugs raise serum potassium — sacubitril/valsartan via angiotensin receptor blockade, spironolactone via aldosteron...
Action
Check potassium and renal function within 1-2 weeks of starting or up-titrating, then every 4 months. Avoid potassium su...
Frequently asked questions
Can I take Sacubitril Valsartan and Spironolactone together?
With caution. Check potassium and renal function within 1-2 weeks of starting or up-titrating, then every 4 months. Avoid potassium supplements and salt substitutes.
What is the severity of this interaction?
The interaction between Sacubitril Valsartan and Spironolactone is classified as Moderate — caution required. Both drugs raise serum potassium — sacubitril/valsartan via angiotensin receptor blockade, spironolactone via aldosterone antagonism — with additive risk of clinically significant hyperkalaemia.
What should I do if I'm prescribed both?
Check potassium and renal function within 1-2 weeks of starting or up-titrating, then every 4 months. Avoid potassium supplements and salt substitutes. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.