Ritonavir and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Rivaroxaban unless specifically directed by your doctor.
How Ritonavir interacts with Rivaroxaban
Ritonavir is a strong inhibitor of both CYP3A4 and P-glycoprotein, the dual elimination pathways for rivaroxaban, leading to markedly increased anticoagulant exposure and bleeding risk.
What you should do
Avoid combination. Consider switching to a vitamin K antagonist or low molecular weight heparin during protease inhibitor therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir is a strong inhibitor of both CYP3A4 and P-glycoprotein, the dual elimination pathways for rivaroxaban, leadin...
Action
Avoid combination. Consider switching to a vitamin K antagonist or low molecular weight heparin during protease inhibito...
Frequently asked questions
Can I take Ritonavir and Rivaroxaban together?
No — this combination should generally be avoided. Avoid combination. Consider switching to a vitamin K antagonist or low molecular weight heparin during protease inhibitor therapy.
What is the severity of this interaction?
The interaction between Ritonavir and Rivaroxaban is classified as Major — avoid combination. Ritonavir is a strong inhibitor of both CYP3A4 and P-glycoprotein, the dual elimination pathways for rivaroxaban, leading to markedly increased anticoagulant exposure and bleeding risk.
What should I do if I'm prescribed both?
Avoid combination. Consider switching to a vitamin K antagonist or low molecular weight heparin during protease inhibitor therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.