Phenobarbital and Rivaroxaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Phenobarbital and Rivaroxaban unless specifically directed by your doctor.
How Phenobarbital interacts with Rivaroxaban
Phenobarbital induces CYP3A4 and P-glycoprotein, both involved in rivaroxaban disposition. This can lower rivaroxaban exposure and increase thromboembolic risk.
What you should do
Avoid coadministration. Consider warfarin with INR monitoring or another anticoagulant strategy not compromised by enzyme induction.
Key facts
Severity
Major — avoid combination
Mechanism
Phenobarbital induces CYP3A4 and P-glycoprotein, both involved in rivaroxaban disposition. This can lower rivaroxaban ex...
Action
Avoid coadministration. Consider warfarin with INR monitoring or another anticoagulant strategy not compromised by enzym...
Frequently asked questions
Can I take Phenobarbital and Rivaroxaban together?
No — this combination should generally be avoided. Avoid coadministration. Consider warfarin with INR monitoring or another anticoagulant strategy not compromised by enzyme induction.
What is the severity of this interaction?
The interaction between Phenobarbital and Rivaroxaban is classified as Major — avoid combination. Phenobarbital induces CYP3A4 and P-glycoprotein, both involved in rivaroxaban disposition. This can lower rivaroxaban exposure and increase thromboembolic risk.
What should I do if I'm prescribed both?
Avoid coadministration. Consider warfarin with INR monitoring or another anticoagulant strategy not compromised by enzyme induction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.