Oral Contraceptive and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Oral Contraceptive and Rifampicin unless specifically directed by your doctor.
How Oral Contraceptive interacts with Rifampicin
Rifampicin induces hepatic enzymes, dramatically reducing contraceptive effectiveness.
What you should do
Use additional contraception during and 28 days after rifampicin course.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces hepatic enzymes, dramatically reducing contraceptive effectiveness.
Action
Use additional contraception during and 28 days after rifampicin course.
Frequently asked questions
Can I take Oral Contraceptive and Rifampicin together?
No — this combination should generally be avoided. Use additional contraception during and 28 days after rifampicin course.
What is the severity of this interaction?
The interaction between Oral Contraceptive and Rifampicin is classified as Major — avoid combination. Rifampicin induces hepatic enzymes, dramatically reducing contraceptive effectiveness.
What should I do if I'm prescribed both?
Use additional contraception during and 28 days after rifampicin course. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.