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Moclobemide and Pethidine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Moclobemide and Pethidine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Moclobemide interacts with Pethidine

Pethidine has serotonergic activity and combined with the MAO-A inhibitor moclobemide can precipitate severe serotonin syndrome with hyperthermia, rigidity and cardiovascular collapse.

What you should do

Combination is contraindicated. Use morphine or another non-serotonergic opioid for analgesia in patients on moclobemide.

Key facts

Severity

Major — avoid combination

Mechanism

Pethidine has serotonergic activity and combined with the MAO-A inhibitor moclobemide can precipitate severe serotonin s...

Action

Combination is contraindicated. Use morphine or another non-serotonergic opioid for analgesia in patients on moclobemide...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Moclobemide and Pethidine together?

No — this combination should generally be avoided. Combination is contraindicated. Use morphine or another non-serotonergic opioid for analgesia in patients on moclobemide.

What is the severity of this interaction?

The interaction between Moclobemide and Pethidine is classified as Major — avoid combination. Pethidine has serotonergic activity and combined with the MAO-A inhibitor moclobemide can precipitate severe serotonin syndrome with hyperthermia, rigidity and cardiovascular collapse.

What should I do if I'm prescribed both?

Combination is contraindicated. Use morphine or another non-serotonergic opioid for analgesia in patients on moclobemide. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.