Mifepristone and Simvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Mifepristone and Simvastatin unless specifically directed by your doctor.
How Mifepristone interacts with Simvastatin
Mifepristone inhibits CYP3A4 and can increase exposure to simvastatin, a CYP3A4 substrate. Increased statin concentrations raise risk of myopathy and rhabdomyolysis.
What you should do
Avoid concurrent use. Hold simvastatin during and shortly after mifepristone treatment according to local guidance.
Key facts
Severity
Major — avoid combination
Mechanism
Mifepristone inhibits CYP3A4 and can increase exposure to simvastatin, a CYP3A4 substrate. Increased statin concentratio...
Action
Avoid concurrent use. Hold simvastatin during and shortly after mifepristone treatment according to local guidance.
Frequently asked questions
Can I take Mifepristone and Simvastatin together?
No — this combination should generally be avoided. Avoid concurrent use. Hold simvastatin during and shortly after mifepristone treatment according to local guidance.
What is the severity of this interaction?
The interaction between Mifepristone and Simvastatin is classified as Major — avoid combination. Mifepristone inhibits CYP3A4 and can increase exposure to simvastatin, a CYP3A4 substrate. Increased statin concentrations raise risk of myopathy and rhabdomyolysis.
What should I do if I'm prescribed both?
Avoid concurrent use. Hold simvastatin during and shortly after mifepristone treatment according to local guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.