Lorazepam and Valproic Acid: Drug Interaction Guide

Quick answer: This combination requires caution. Lorazepam and Valproic Acid can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Lorazepam interacts with Valproic Acid

Valproic acid inhibits glucuronidation of lorazepam, reducing its clearance and increasing sedation and psychomotor impairment.

What you should do

Use the lowest effective lorazepam dose and monitor for excessive sedation or respiratory depression. A substantial initial lorazepam dose reduction may be appropriate.

Key facts

Severity

Moderate — caution required

Mechanism

Valproic acid inhibits glucuronidation of lorazepam, reducing its clearance and increasing sedation and psychomotor impa...

Action

Use the lowest effective lorazepam dose and monitor for excessive sedation or respiratory depression. A substantial init...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lorazepam and Valproic Acid together?

With caution. Use the lowest effective lorazepam dose and monitor for excessive sedation or respiratory depression. A substantial initial lorazepam dose reduction may be appropriate.

What is the severity of this interaction?

The interaction between Lorazepam and Valproic Acid is classified as Moderate — caution required. Valproic acid inhibits glucuronidation of lorazepam, reducing its clearance and increasing sedation and psychomotor impairment.

What should I do if I'm prescribed both?

Use the lowest effective lorazepam dose and monitor for excessive sedation or respiratory depression. A substantial initial lorazepam dose reduction may be appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.