Lorazepam and Valproate: Drug Interaction Guide

Quick answer: This combination requires caution. Lorazepam and Valproate can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Lorazepam interacts with Valproate

Valproate inhibits lorazepam glucuronidation and may increase lorazepam exposure, while both drugs contribute to central nervous system depression.

What you should do

Use a lower lorazepam dose when necessary and monitor for excessive sedation, impaired coordination, and respiratory depression.

Key facts

Severity

Moderate — caution required

Mechanism

Valproate inhibits lorazepam glucuronidation and may increase lorazepam exposure, while both drugs contribute to central...

Action

Use a lower lorazepam dose when necessary and monitor for excessive sedation, impaired coordination, and respiratory dep...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lorazepam and Valproate together?

With caution. Use a lower lorazepam dose when necessary and monitor for excessive sedation, impaired coordination, and respiratory depression.

What is the severity of this interaction?

The interaction between Lorazepam and Valproate is classified as Moderate — caution required. Valproate inhibits lorazepam glucuronidation and may increase lorazepam exposure, while both drugs contribute to central nervous system depression.

What should I do if I'm prescribed both?

Use a lower lorazepam dose when necessary and monitor for excessive sedation, impaired coordination, and respiratory depression. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.