Lithium and Nsaids: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lithium and Nsaids unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lithium interacts with Nsaids

NSAIDs reduce renal prostaglandin synthesis, decreasing renal blood flow and lithium clearance. This can raise lithium concentrations and precipitate toxicity.

What you should do

Avoid regular NSAID use in patients taking lithium when possible. If an NSAID is necessary, monitor lithium levels and renal function shortly after initiation and adjust lithium dose.

Key facts

Severity

Major — avoid combination

Mechanism

NSAIDs reduce renal prostaglandin synthesis, decreasing renal blood flow and lithium clearance. This can raise lithium c...

Action

Avoid regular NSAID use in patients taking lithium when possible. If an NSAID is necessary, monitor lithium levels and r...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lithium and Nsaids together?

No — this combination should generally be avoided. Avoid regular NSAID use in patients taking lithium when possible. If an NSAID is necessary, monitor lithium levels and renal function shortly after initiation and adjust lithium dose.

What is the severity of this interaction?

The interaction between Lithium and Nsaids is classified as Major — avoid combination. NSAIDs reduce renal prostaglandin synthesis, decreasing renal blood flow and lithium clearance. This can raise lithium concentrations and precipitate toxicity.

What should I do if I'm prescribed both?

Avoid regular NSAID use in patients taking lithium when possible. If an NSAID is necessary, monitor lithium levels and renal function shortly after initiation and adjust lithium dose. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.